TITLE

Green-coloured results on guaiac-based faecal occult blood testing should be considered positive

AUTHOR(S)
Gordon, Joy C; Steele, RJC; Fraser, CG
PUB. DATE
November 2004
SOURCE
Annals of Clinical Biochemistry;Nov2004, Vol. 41 Issue 6, p488
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: In guaiac-based faecal occult blood tests (FOBT), blue colours are considered positive. Blue-green colours should also be considered positive. Distinct green colours are said to be due to bile and it is stated that these should be interpreted as negative. The purpose of this study was to determine the clinical outcomes in individuals in whom the FOBT had difficult-to-interpret green colours that did not wash out on addition of developer. Methods: During the examination of 134 844 FOBT received in the Scottish laboratory in the first screening round of the UK Colorectal Cancer Screening Pilot, samples with green colour that did not wash out during development were identified. The clinical outcomes were determined from the comprehensive data set collected for each participant. Results: A small number (77) of FOBT were recorded as green-coloured on development. These were reported as positive and the usual investigation algorithm followed. Significant pathology was present in 31 of the 77 participants (40.3%). Negative outcomes encompassed 39 of the 77 participants (50.6%). The outcome could not be determined accurately for seven of the 77 participants (9.1%). Importantly, 17 of the participants (22.1%) had polyps. Conclusions: Any green colour that does not wash out to the periphery of the guaiac tape on development of FOBT should be reported as a positive result, and manufacturers should clarify their instructions on interpretation.
ACCESSION #
22630852

 

Related Articles

  • Delayed cholangitis due to a retained T-tube fragment. Kourosh, Shamimi; Fereydon, Moazami; Mehdi, Jalali; Ali, Aminian // Indian Journal of Surgery;Dec2006, Vol. 68 Issue 6, p328 

    Biliary drainage with T-tube after bile duct exploration has some advantages. However, the use of T-tube is associated with significant complications. Retained T-tube fragment is a rare complication after biliary surgery. We present an unusual case of delayed cholangitis resulting from a...

  • Palliation for Extrahepatic Biliary Obstruction by Metastatic Colorectal Carcinoma. Chung Yau Lo; Lai, Edward C. S. // American Journal of Gastroenterology;Oct1994, Vol. 89 Issue 10, p1852 

    Objectives: Extrahepatic biliary obstruction due to metastatic colorectal carcinoma, though rare, can account for the occurrence of obstructive jaundice even in the presence of hepatic metastases. The present report aims at reviewing our experience with the palliative treatment of these...

  • Announcements.  // American Journal of Gastroenterology;Dec1997, Vol. 92 Issue 12, p2336 

    Provides information on several activities involving the field of gastroenterology as of December 1997. 5th International Symposium on Pancreatic and Biliary Endoscopy; 15th Annual Gastroenterology Update: An Interdisciplinary and Interactive Approach; Colorectal Disease in 1998.

  • Cholecystectomy and the Risk of Colorectal Cancer. Theresa Shao; Yu-Xiao Yang // American Journal of Gastroenterology;Aug2005, Vol. 100 Issue 8, p1813 

    OBJECTIVES: Cholecystectomy has been implicated as a possible risk factor for colorectal cancer. However, the clinical evidence and the underlying mechanism for this association are still inconclusive. We conducted a population-based study to further clarify this association. METHODS: We...

  • Surgery of liver metastases from colorectal cancer: new promises. Penna, Christophe; Nordlinger, Bernard // British Medical Bulletin;Dec2002, Vol. 64 Issue 1, p127 

    For a long time, patients with liver metastases from colorectal cancer were considered to be incurable. Over the last 30 years, the benefits of surgical resection and systemic chemotherapy have been established. Actually, surgical resections are feasible with a very low mortality and a 5-year...

  • Performance Characteristics and Evaluation of an Automated-Developed and Quantitative, Immunochemical, Fecal Occult Blood Screening Test. Vilkin, Alex; Rozen, Paul; Levi, Zohar; Waked, Amal; Maoz, Eran; Birkenfeld, Shlomo; Niv, Yaron // American Journal of Gastroenterology;Nov2005, Vol. 100 Issue 11, p2519 

    OBJECTIVES: Guaiac fecal occult blood colorectal cancer (CRC) screening tests (FOBT) are faulted for low sensitivity and nonspecificity for human hemoglobin (Hb). Automated-developed, immunochemical, human Hb FOBT (I-FOBT) is specific, eliminates diet restrictions, and Hb quantification allows...

  • PI-48*. Ghibellini, G.; Vasist, L. S.; Heizer, W. D.; Kowalsky, R. J.; Brouwer, K. L. // Clinical Pharmacology & Therapeutics;Feb2006, Vol. 79 Issue 2, pP19 

    Background/aims: Tc-99m sestamibi (MIBI), a myocardial imaging agent, is a P-gp, MRP1, Mrp2, and BCRP substrate. This study was designed to assess Tc-99m MIBI biliary clearance in healthy volunteers utilizing a customized oroenteric tube and clinical protocol.Methods: This open-label study was...

  • Evaluating Rectal Bleeding.  // Tufts University Health & Nutrition Letter;Dec2001, Vol. 19 Issue 10, p4 

    Reports a case study of a patient suffering from a colorectal cancer in the U.S. Symptoms of the disease; Importance of blood test in patients with colorectal cancer; Causes of rectal bleeding.

  • Colon cancer: How to guard your gut.  // Consumer Reports on Health;Oct99, Vol. 11 Issue 10, p5 

    Discusses the diagnosis, protective diet and other preventive strategies for colon cancer. INSETS: Do the tests have to hurt?;High risk, special steps.;Know the warning signs..

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics