Limitation of the Vitrosâ„¢ dry-slide technique in measuring high concentrations of salicylate in plasma

Iversen, S. A.; Walker, A.; Avades, T. Y.; Wilson, J. F.
November 2001
Annals of Clinical Biochemistry;Nov2001, Vol. 38 Issue 6, p711
Academic Journal
The linearity of the Vitrosâ„¢ dry-slide method for plasma salicylate was assessed in two ways: serial concentrations of sodium salicylate were added to fresh lithium heparin plasma, and the salicylate was determined both neat and in dilution. Vitros salicylate results submitted to the Heathcontrol External Quality Assessment Scheme were compared to the spike value. Similar loss of linearity was observed in both cases. Serious salicylate overdosage requiring specific clinical treatment may have been underestimated.


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