TITLE

Lymphatic Mapping with Sentinel Lymph Node Biopsy in Patients with Breast Cancers<1 centimeter

AUTHOR(S)
Bass, Siddharth S.; Dauway, Emilia
PUB. DATE
September 1999
SOURCE
American Surgeon;Sep1999, Vol. 65 Issue 9, p857
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Because of its high cost and attendant morbidity, the necessity of axillary dissection in patients with small invasive primary tumors has been questioned. Lymphatic mapping with sentinel lymph node (SLN) biopsy is an alternative to complete axillary dissection; however, researchers have excluded patients with T[sub 1A]-T[sub 1B] lesions. Seven hundred patients with newly diagnosed breast cancers underwent an Institutional Review Board-approved prospective trial of intraoperative lymphatic mapping using a combination of Lymphazurin and filtered technetium-labeled sulfur colloid. An SLN was defined as a blue node and/or hot node with a 10:1 ex vivo radioactivity ratio in the SLN verus non-SLNs. All SLNs were evaluated by both hematoxylin and eosin and cytokeratin immunohistochemical stains. Of the 700 patients, 665 (95.0%) were mapped successfully. One hundred ninety-six (28.0%) had T[sub 1A]-T[sub 1B] tumors. Forty patients (20.4%) with T[sub 1A]-T[sub 1B] tumors had metastases to the SLNs. We conclude that breast cancer SLN mapping is highly accurate and sensitive when combined dye techniques (radiocolloid and vital blue dye) are utilized. This technique is particularly useful in patients with small invasive primary tumors, which, despite their size, still demonstrate a significant rate of axillary metastasis. These patients should not be excluded from lymphatic mapping protocols.
ACCESSION #
2258989

 

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