TITLE

Synthesis of the Antimycobacterial Naphthoquinone, 7-Methyljuglone and its Dimer, Neodiospyrin

AUTHOR(S)
Van Der Kooy, Frank; Meyer, J. J. Marion
PUB. DATE
March 2006
SOURCE
South African Journal of Chemistry;2006, Vol. 59, p60
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We report on the laboratory-scale synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone (7-methyl-5-hydroxy-1,4-naphthoquinone) in a one step Friedel-Crafts acylation reaction. This compound was used to synthesize neodiospyrin, which possesses similar bioactivity.
ACCESSION #
22546401

Tags: MICROBIOLOGICAL synthesis;  NAPHTHOQUINONE;  FRIEDEL-Crafts reaction;  ACYLATION;  BIOSYNTHESIS

 

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