Human T-cell lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma in the Inuit people of Nunavut

Fahim, Simone; Prokopetz, Robert; Jackson, Robert; Faught, Carolyn; McCarthy, Anne E.; Andonov, Anton; Coulthart, Michael; Daw, Zohra; Olberg, Bernard; Giulivi, Antonio; Padmore, Ruth
September 2006
CMAJ: Canadian Medical Association Journal;9/12/2006, Vol. 175 Issue 6, p579
Academic Journal
The article presents three cases of human T-cell lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL) found in three Inuit women from Nunavut. One patient presented with a 2-week history of malaise, pain in the right upper abdominal quadrant and mild jaundice. The other patient exhibited a nonspecific eczematous follicular dermatitis, while the other one presented with fever and shortness of breath.


Related Articles

  • Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats. Ching-Ping Chan; Yeung-Tung Siu; Kin-Hang Kok; Yick-Pang Ching; Hei-Man Vincent Tang; Dong-Yan Jin // Retrovirology;2013, Vol. 10 Issue 1, p1 

    Background: Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and tropical spastic paraparesis. HTLV-1 encodes transactivator protein Tax that interacts with various cellular factors to modulate transcription and other biological functions. Additional...

  • The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth. D'Agostino, D M; Silic-Benussi, M; Hiraragi, H; Lairmore, M D; Ciminale, V // Cell Death & Differentiation;Aug2005 Supplement, Vol. 12, p905 

    p13II of human T-cell leukemia virus type 1 (HTLV-1) is an 87-amino-acid protein that is targeted to the inner mitochondrial membrane. p13II alters mitochondrial membrane permeability, producing a rapid, membrane potential-dependent influx of K+. These changes result in increased mitochondrial...

  • HTLV-I PROVIRUS IN THE CLINICAL SUBTYPES OF ATL. MATSUOKA, Masao; TAMIYA, Sadahiro; TAKEMOTO, Shigeki; YAMAGUCHI, Kazunari; TAKATSUKI, Kiyoshi // Leukemia (08876924);Apr97 Supplement 3, Vol. 11, p67 

    Adult T cell leukemia (ATL) is an aggressive neoplasm of mature helper T cell, which is etiologically linked with human T-lymphotropic virus type I (HTLV-I). We studied HTLV-I provirus in 61 cases of ATL with Southern blot analyses and long PCR. These methods detected defective virus in 34 cases...

  • Adult T-cell leukemia in India: Report of two cases and review of literature. Karthik, Udupa; Ganesan, Prasanth; Sagar, Tenali Gnana; Cyriac, Sanju; Majhi, Urmila // Journal of Cancer Research & Therapeutics;Jul-Sep2011, Vol. 7 Issue 3, p338 

    The article presents case studies of adult T-cell leukemia lymphoma (ATLL) in India. It reports the implication of Human T Lymphotropic Virus type I (HTLV-I) in the pathogenesis of ATLL in which 2% of HTLV-I infected patients develop ATLL and 95% show serologic evidence of HTLV-I. It mentions...

  • Severe refractory hypercalcaemia in HTLV-1 infection. Edwards, C. Mark B.; Edwards, Sarah J. E.; Bhumbra, Rej-Paul; Chowdhury, Tahseen A. // Journal of the Royal Society of Medicine;Mar2003, Vol. 96 Issue 3, p126 

    The article presents case studies and comments on severe refractory hypercalcaemia in human T-cell leukaemia virus type-1(HTLV-1) infection. Adult T-cell leukaemia / lymphoma (ATLL) is known to be caused by HTLV-1 which is endemic in Japan, the Caribbean, central and South America and Africa....

  • PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. Kozako, T.; Yoshimitsu, M.; Fujiwara, H.; Masamoto, I.; Horai, S.; White, Y.; Akimoto, M.; Suzuki, S.; Matsushita, K.; Uozumi, K.; Tei, C.; Arima, N. // Leukemia (08876924);Feb2009, Vol. 23 Issue 2, p375 

    Adult T-cell leukemia/lymphoma (ATLL) develops after infection with human T-cell leukemia virus-1 (HTLV-1) after a long latency period. The negative regulatory programmed death-1/programmed death-1 ligand 1 (PD-1/PD-L1) pathway has been implicated in the induction of cytotoxic T-lymphocyte (CTL)...

  • Human T-Lymphotropic Viruses Evolution Possibly Explained by Primate Deltaretrovirus Geographical Segregation. Barros Kanzaki, Luis Isamu; Casseb, Jorge // Retrovirology: Research & Treatment;2008, Issue 1, p15 

    The primate T cell lymphotropic virus group comprises pathogenic and apathogenic agents found in human and simian hosts. Up to date, three types of the simian T cell lymphotropic virus/STLV and four types of the human T cell lymphotropic virus/HTLV have been isolated and characterized from non...

  • The Prevalence and Significance of HTLV-I/II Seroindeterminate Western Blot Patterns. Abrams, Anna; Akahata, Yoshimi; Jacobson, Steven // Viruses (1999-4915);Aug2011, Vol. 3 Issue 8, p1320 

    Human T-lymphotropic virus type I (HTLV-I) infects an estimated 15-20 million persons worldwide. A number of diseases have been associated with the virus including adult T-cell leukemia (ATL), HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), HTLV-I uveitis, and...

  • Human T-cell Leukemia Virus. Levy, Jay A.; Murphy, Edward L. // Encyclopedic Reference of Cancer;2001, p435 

    An encyclopedia entry for "human T-cell leukemia virus (HTLV)" is presented. It refers to a human retrovirus that is associated with adult T cell leukemia and topical spastic paraparesis. HTLV-I is the most common type of HTLV and is consistently associated with diseases. HLTV may be present in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics