TITLE

EFFECT OF EARLY FULL WEIGHT-BEARING AFTER JOINT INJURY ON INFLAMMATION AND CARTILAGE DEGRADATION

AUTHOR(S)
Green, D. M.; Noble, P. C.; Bocell Jr., J. R.; Ahuero, J. S.; Poteet, B. A.; Birdsall, H. H.
PUB. DATE
October 2006
SOURCE
Journal of Bone & Joint Surgery, American Volume;Oct2006, Vol. 88-A Issue 10, p2201
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Early full weight-bearing after an acute osteochondral injury avoids problems associated with immobility but may also be harmful by amplifying the inflammatory response. To investigate these effects, we developed an in vivo model of subchondral trauma. Methods: After an impact injury to the femoral condyle, fourteen dogs were randomized to immediate full weight-bearing or to four weeks of minimal weight-bearing before full weight-bearing. Synovial fluid was sampled by aspiration at one, two, four, eight, twelve, sixteen, twenty, and twenty-four weeks. Neutrophils, monocytes, and lymphocytes were enumerated, and the concentrations of tumor necrosis factor-alpha, interleukin-10, nitric oxide, matrix metalloproteinases, and glycosaminoglycans were measured. Results: Compared with the findings for uninjured joints, the synovial fluid from the impacted joints of full-weight-bearing dogs had significantly higher peak concentrations of neutrophils (p = 0.0006 at one week), mononuclear leukocytes (p = 0.001 at four weeks), tumor necrosis factor-alpha (p = 0.001 at one week), nitric oxide (p = 0.001 at one week), matrix metalloproteinases (p = 0.008 at one week), and glycosaminoglycans (p = 0.002 at four weeks and p = 0.001 at six months). The size of the bone bruise correlated with the peak concentrations of tumor necrosis factoralpha (r² = 0.89, p = 0.007; Spearman rank test), matrix metalloproteinases (r² = 0.96, p = 0.0004), and glycosaminoglycans (r² = 0.96, p = 0.0004). However, restriction to minimal weight-bearing for four weeks after the injury led to a significant reduction in the synovial fluid concentrations of neutrophils (p = 0.007 at one week and p = 0.01 at two weeks), tumor necrosis factor-alpha (p = 0.0006 to 0.02 during the first four weeks), nitric oxide (p = 0.001 to 0.04 during the first four weeks), and matrix metalloproteinases (p = 0.007 to 0.01 from the second week to the eighth week). In contrast, interleukin-10 concentrations were significantly higher (p = 0.002 at one week) and glycosaminoglycan levels remained at normal levels in animals that were restricted from immediate full weight-bearing after the injury. Conclusions: The magnitude of the inflammatory response is proportional to the size of the bone bruise. Restriction to minimal weight-bearing for four weeks reduces the magnitude of the inflammatory response and the cartilage degradation following articular cartilage impact injury. Clinical Relevance: Strategies to minimize mechanical stress during the early postinjury period may help to preserve cartilage integrity and forestall the development of osteoarthritis.
ACCESSION #
22449148

 

Related Articles

  • Significance of Negative Cultures in the Treatment of Acute Hematogenous Bone and Joint Infections in Children. Pääkkönen, Markus; Kallio, Markku J. T.; Kallio, Pentti E.; Peltola, Heikki // Journal of the Pediatric Infectious Diseases Society;Jun2013, Vol. 2 Issue 2, p119 

    Background Synovial fluid and blood cultures often remain negative in acute bone and joint infections of childhood even when characteristic symptoms, signs, and/or radiologic proof are present. Methods We analyzed 345 prospectively documented osteoarticular infections in children at age 3 months...

  • Tracking Taphonomic Regimes Using Chemical and Mechanical Damage of Pollen and Spores: An Example from the Triassic-Jurassic Mass Extinction. Mander, Luke; Wesseln, Cassandra J.; McElwain, Jennifer C.; Punyasena, Surangi W. // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    The interpretation of biotic changes in the geological past relies on the assumption that samples from different time intervals represent an equivalent suite of natural sampling conditions. As a result, detailed investigations of taphonomic regimes during intervals of major biotic upheaval, such...

  • Clinical and radiographic study of bone and joint lesions in 26 dogs with leishmaniasis. Agut, A.; Corzo, N.; Murciano, J.; Laredo, F.G.; Soler, M. // Veterinary Record: Journal of the British Veterinary Association;11/22/2003, Vol. 153 Issue 21, p648 

    Twenty-six dogs with parasitologically confirmed leishmaniasis and abnormalities of gait were studied to determine the most common radiological patterns of bone and joint lesions. The clinical findings included either lameness, joint pain and crepitation, soft tissue swelling and/or muscle...

  • haemarthrosis. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p354 

    An encyclopedia entry for "haemarthrosis" is presented. It refers to bleeding that occurs into a joint, which results to swelling in the capsule that encloses the joint, causing pain and stiffness. It is commonly caused by severe injury to a joint, such as a torn capsule, torn ligaments or...

  • Correlation between the surface area of synovial membrane and the surface area of articular cartilage in synovial joints of the mouse and human. Hewitt, Kylie M.; Stringer, Mark D. // Surgical & Radiologic Anatomy;Nov2008, Vol. 30 Issue 8, p645 

    Articular cartilage is avascular. Evidence suggests that in mature animals synovial fluid is the dominant source of nutrition for articular cartilage. If so, there might be a direct correlation between the surface area of synovial membrane and the surface area of articular cartilage in synovial...

  • Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep. Sidler, Michèle; Fouché, Nathalie; Meth, Ingmar; von Hahn, Friedrich; von Rechenberg, Brigitte; Kronen, Peter W. // BMC Veterinary Research;2014, Vol. 10 Issue 1, p1 

    Background The present preliminary study describes concentration time courses of the NSAID carprofen in the plasma and synovial fluid in a microfrature sheep model after transcutaneous treatments with a novel application device (Vetdrop®). To treat circumscribed inflammatory processes a...

  • The articular joint and its intriguing gliding surfaces. Brittberg, Mats // Knee Surgery, Sports Traumatology, Arthroscopy;Jun2014, Vol. 22 Issue 6, p1205 

    An introduction to the journal is presented in which the editor discusses various reports related to cartilage published within the issue, including treatment of osteochondritis dissecans (OCD), clinical repairs in the knee and in the ankle, and treatment of osteochondral injuries of the elbow.

  • Detección de glicosaminoglicanos de la matriz del cartílago articular en el líquido sinovial de carpo equino con fractura en esquirla. Adarmes, H.; Vásquez, F.; Galleguillos, M.; González, E. // Archivos de Medicina Veterinaria;2008, Vol. 40 Issue 1, p77 

    The purpose of this study was to establish if the duration of chip fracture in equine carpal joint of purebred horses, affects the synovial concentration of total glycosaminoglycans (GAGsT) and glycosaminoglycans that are different from hyaluronic acid or sulfated GAGs (GAGsS). Two groups of...

  • Unusual synovial Fluid Findings in Reiter's Syndrome. Pekin, Thomas J.; Malinin, Theodore I.; Zvaifler, Nathan J. // Annals of Internal Medicine;Apr67, Vol. 66 Issue 4, p677 

    Presents information on a study which reported two unusual findings in the synovial fluid from patients with Reiter's syndrome, which are higher hemolytic complement levels and the presence of macrophages. Patient information; Synovial fluid examination; Information on synovial fluid findings;...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics