Role of corticotropin-releasing factor in stress-related visceral hyperalgesia

Kaneko, Hiroshi
August 2006
Journal of Gastroenterology;Aug2006, Vol. 41 Issue 8, p810
Academic Journal
The author reflects on the function of corticotropin-releasing factor (CRF) in stress-related visceral hyperalgesia. He mentions CRF's other term which is corticotropin-releasing hormone, a novel 41-amino-acid hypothalamic peptide that stimulates the release and synthesis of beta-endorphin and adrenocorticotropic hormone from the pituitary. An overview of the relation of immune system and molecular component of visceral hyperalgesia in the animal models is offered.


Related Articles

  • Can modulating corticotropin releasing hormone receptors alter visceral sensitivity? Fukudo, S.; Saito, K.; Sagami, Y.; Kanazawa, M. // Gut;Feb2006, Vol. 55 Issue 2, p146 

    Activation of corticotropin releasing hormone (CRH) receptor 2 (CRH-R2) reduces visceral sensitivity induced by colorectal distension in conscious rats. This finding is relevant to the increased interest in the potential use of therapeutic agents that act on CRH receptors in the treatment of...

  • CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1 /2 phosphorylation in rats. Million, M.; Wang, L.; Wang, Y.; Adelson, D. W.; Yuan, P-Q.; Maillot, C.; Coutinho, S. V.; Mcroberts, J. A.; Bayati, A.; Mattsson, H.; Wu, V.; Wei, J-Y.; Rivier, J.; Vale, W.; Mayer, E. A.; Taché, V. // Gut;Feb2006, Vol. 55 Issue 2, p172 

    Background and aims: Activation of corticotropin releasing factor 1 (CRF1) receptors is involved in stress related responses and visceral pain, while activation of CRF2 receptors dampens the endocrine and some behavioural stress responses. We hypothesised that CRF2 receptor activation may...

  • Hormones, Neurons and Anxiety.  // BioWorld Today;9/6/2011, Vol. 22 Issue 172, Special section p2 

    The article discusses a study, conducted by researchers from the German Max Planck Institute for Psychiatry, which presented new insights into corticotropin-releasing hormone receptor 1 (CRHR1).

  • Corticotropin-Releasing Factor Receptor Antagonists in Affective Disorders and Drug Dependence - An Update. Steckler, Thomas; Dautzenberg, Frank M. // CNS & Neurological Disorders - Drug Targets;2006, Vol. 5 Issue 2, p147 

    Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF1 and CRF2) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse. The molecular characterization of CRF1 and CRF2 receptors and their splice variants has generated...

  • The Role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications. Lloyd, R. Brett; Nemeroff, Charles B. // Current Topics in Medicinal Chemistry;Mar2011, Vol. 11 Issue 6, p609 

    Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research...

  • CRF Receptor Antagonists: Utility in Research and Clinical Practice. Chatzaki, E.; Minas, V.; Zoumakis, E.; Makrigiannakis, A. // Current Medicinal Chemistry;2006, Vol. 13 Issue 23, p2751 

    CRF, CRF-related peptides and CRF receptors constitute a complex physiological system which has a key role in facilitating the adaptation of the organism to the stressful stimuli of the environment. The behavioral, endocrine, autonomic and immune branches of stress response are considered to be...

  • Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Post, Anke; Ohl, Frauke; Almeida, Osborne F. X.; Binder, Elisabeth B.; Rücker, Monika; Welt, Sandra; Binder, Elke; Holsboer, Florian; Sillaber, Inge // Psychopharmacology;Jun2005, Vol. 180 Issue 1, p150 

    Presents a study which discussed the molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone (CRH) receptor 1 antagonist NBI30775. Role of the neuropeptide CRH; Link between the hyperactivity of the hypothalamic-pituitary-adrenal axis with mood and...

  • Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Licinio, J.; O'Kirwan, F.; Irizarry, K.; Merriman, B.; Thakur, S.; Jepson, R.; Lake, S.; Tantisira, K. G.; Weiss, S. T.; Wong, M.-L. // Molecular Psychiatry;Dec2004, Vol. 9 Issue 12, p1075 

    There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We...

  • Behavioural genetics: Dipsomaniac mice? López, Juan Carlos // Nature Reviews Genetics;Jun2002, Vol. 3 Issue 6, p408 

    Discusses research on the enhanced and delayed stress-induced alcohol drinking in mice lacking functional corticotropin-releasing hormone (CRH). Reference to a study by L. Sillaber and colleagues published in the 2002 issue of "Science" journal; Influence of stress on alcohol intake; CRH...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics