Mitchel, J. T.; Vicaria, M.; Eyerdam, D. H.; Meinking, T. M.
February 2006
Clinical Pharmacology & Therapeutics;Feb2006, Vol. 79 Issue 2, pP9
Academic Journal
Pediculosis is increasing rapidly in the US and throughout the world due to drug resistance. This new investigational treatment for head lice, L.A. is pesticide free, works as a suffocant, will not cause resistance, and is environmentally safe. The mechanism of action of L.A. is to stun the respiratory spiracles open, thus enabling the treatment to mechanically block the respiratory system. Two randomized, observer-blinded, dose ranging Phase II clinical trials were conducted to evaluate the safety and efficacy of L.A. There were two treatments of 10 minutes each, one week apart. Subjects came from an area of high lice infestation. There were 81 subjects who entered and 79 who completed study 1; 42 subjects were entered and 39 completed study 2. The primary efficacy variable was the % of subjects with treatment success at the end of the study. On Day 1 post-treatment in Study 1, L.A. (5% and 10%) and RID treatment groups had ≤2.0 mean live lice, while the vehicle placebo group had a mean of 7.7 live lice (p=0.004). Kill rate was >80% in those receiving active treatment compared to <20% in the placebo group (p<0.001). At Day 15, all treatments demonstrated 70% success. In the minimum effective dose study, the hair was fully saturated during treatment. Results showed that 5% and 2.5% L.A. demonstrated an overall treatment success of 90.5% and 81.0%, respectively. Five subjects experienced expected adverse events during study 1, and 1 subject in study 2. The L.A. 5% treatment was efficacious and the dose of choice.Clinical Pharmacology & Therapeutics (2005) 79, P9–P9; doi: 10.1016/j.clpt.2005.12.030


Related Articles

  • PI-9. Mitchel, J. T.; Vicaria, M.; Eyerdam, D. H.; Meinking, T. M. // Clinical Pharmacology & Therapeutics;Feb2006, Vol. 79 Issue 2, pP9 

    Pediculosis is increasing rapidly in the US and throughout the world due to drug resistance. This new investigational treatment for head lice, L.A. is pesticide free, works as a suffocant, will not cause resistance, and is environmentally safe. The mechanism of action of L.A. is to stun the...

  • Measuring the Economic Costs of Antimicrobial Resistance in Hospital Settings: Summary of the Centers for Disease Control and Prevention--Emory Workshop. Howard, David; Cordell, Ralph; McGowan Jr., John E.; Packard, Randall M.; Scott II, R. Douglas; Solomon, Steven L. // Clinical Infectious Diseases;11/1/2001, Vol. 33 Issue 9, p1573 

    Provides information on a workshop which discussed the advantages and disadvantages of various research designs and methodologies related to the measurement of the economic cost of drug-resistance in health care settings. Information on resistance-related costs; Problems in measuring the...

  • Drug resistance pattern of Pseudomonas aeruginosa isolates at PIMS Hospital, Islamabad, Pakistan. Khan, Jafar; Wahab, Abdul; Qayyum, Arshad; Jamshed, Shahbreen // Journal of Chemical & Pharmaceutical Research;2014, Vol. 6 Issue 11, p715 

    Pseudomonas aeruginosa is an opportunistic pathogen causing serious nosocomial infections in patients. Emergence of multi-drug resistant P. aeruginosa is an increasing infection control problem leading to high morbidity and mortality. Extended spectrum beta-lactamase enzymes are the increasing...

  • Proposed Bush budget favors NIH. Ready, Tinker // Nature Medicine;Jun2001, Vol. 7 Issue 6, p644 

    Focuses on the budget proposed by U.S. President George W. Bush for the National Institutes of Health in the United States. Controversies regarding the government funding for research and development projects; Reasons for support for medical-research funding by the government.

  • Medical News & Perspectives.  // JAMA: Journal of the American Medical Association;5/22/2002, Vol. 287 Issue 20, p2639 

    Discusses the limitations of the extant bioterrorism treatment system in the United States for research oversight, following an outbreak of anthrax. Suggestion that the various rules designed to vet prospective research act as impediments to quick action during possible future emergencies;...

  • Observations. Formanek Jr., Raymond // FDA Consumer;Nov/Dec2006, Vol. 40 Issue 6, p2 

    The article presents updates on public health-related issues in the U.S. Bogus health promotions, scams, and cures are enforcement priorities for both the Federal Trade Commission and the Food and Drug Administration (FDA). The proliferation of such promotions prompted the government agencies to...

  • Incarceration as a key variable in racial disparities of asthma prevalence. Wang, Emily A.; Green, Jeremy // BMC Public Health;2010, Vol. 10 Issue 1, p290 

    Background: Despite the disproportionate incarceration of minorities in the United States, little data exist investigating how being incarcerated contributes to persistent racial/ethnic disparities in chronic conditions. We hypothesized that incarceration augments disparities in chronic disease....

  • US government issues guidelines on conflicts of interest in research. Marwick, Charles // BMJ: British Medical Journal (International Edition);4/12/2003, Vol. 326 Issue 7393, p782 

    Discusses how the United States Department of Health and Human Services has issued guidelines on what clinical researchers should do to avoid financial conflicts of interest. How the department's guidelines list 24 points for institutions and investigators to remember; Suggestion that...

  • Molecular mechanisms of converting K562/DNR cellular drug-resistance by bortezomib. LI, Y.-C.; WANG, H.-H.; LIAO, A.-J.; FU, B.-B.; ZHANG, R.; LI, J.; YANG, Y.; LIU, Z.-G.; YANG, W. // European Review for Medical & Pharmacological Sciences;Jun2014, Vol. 18 Issue 11, p1465 

    OBJECTIVES: The aim of this study was to observe the effects of bortezomib (PS341) on the expression of NF-κB (nuclear factor-kappa B), IκB (inhibitor kB) and P-gp (P-glycoprotein) of K562 cells induced by daunoru-bicin (K562/DNR). MATERIALS AND METHODS: MTT method was used to determine...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics