TITLE

Understanding the role of progranulin in Alzheimer's disease

AUTHOR(S)
D'Alton, Simon; Lewis, Jada
PUB. DATE
October 2014
SOURCE
Nature Medicine;Oct2014, Vol. 20 Issue 10, p1099
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the the role of progranulin in Alzheimer's disease (Ad). Topics discussed include the role of progranulin can be use to modify AD-relevant phenotypes, the impaired phagocytosis may contribute to amyloidosis in the development of AD, and it can protect against the toxic effects of amyloid in neuronal cell culture.
ACCESSION #
22412421

 

Related Articles

  • Understanding the role of progranulin in Alzheimer's disease. D'Alton, Simon; Lewis, Jada // Nature Medicine;Oct2014, Vol. 20 Issue 10, p1099 

    The article discusses the the role of progranulin in Alzheimer's disease (Ad). Topics discussed include the role of progranulin can be use to modify AD-relevant phenotypes, the impaired phagocytosis may contribute to amyloidosis in the development of AD, and it can protect against the toxic...

  • Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice. Chu, J; Li, J-G; Giannopoulos, P F; Blass, B E; Childers, W; Abou-Gharbia, M; Praticò, D // Molecular Psychiatry;Nov2015, Vol. 20 Issue 11, p1329 

    The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein...

  • Adaptogenic and nootropic activity of Mimosa pudica in albino wistar rats. Ittiyavirah, Sibi Perumbamkudiyil; Pullochal, Ibrahim // International Journal of Nutrition, Pharmacology, Neurological D;Oct-Dec2014, Vol. 4 Issue 4, p231 

    Aim: To evaluate the adoptogenic activity of ethanolic extract of Mimosa pudica L. in chronic Alzheimer's model. Materials and Methods: The dried whole part of the plant were subjected to hot continuous extraction method using ethanol as solvent and were standardized using pharmacognostical and...

  • CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. Krauthausen, Marius; Kummer, Markus P.; Zimmermann, Julian; Reyes-Irisarri, Elisabet; Terwel, Dick; Bulic, Bruno; Heneka, Michael T.; Müller, Marcus // Journal of Clinical Investigation;Jan2015, Vol. 125 Issue 1, p365 

    Chemokines are important modulators of neuroinflammation and neurodegeneration. In the brains of Alzheimer's disease (AD) patients and in AD animal models, the chemokine CXCL10 is found in high concentrations, suggesting a pathogenic role for this chemokine and its receptor, CXCR3. Recent...

  • Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system. Bedussi, Beatrice; van Lier, Monique G. J. T. B.; Bartstra, Jonas W.; de Vos, Judith; Siebes, Maria; VanBavel, Ed; Bakker, Erik N. T. P. // Fluids & Barriers of the CNS;10/5/2015, Vol. 12 Issue 1, p1 

    Background: In the absence of a true lymphatic system in the brain parenchyma, alternative clearance pathways for excess fluid and waste products have been proposed. Suggested mechanisms for clearance implicate a role for brain interstitial and cerebrospinal fluids. However, the proposed...

  • The protective effect of Borago Officinalis extract on amyloid β (25-35)-induced long term potentiation disruption in the dentate gyrus of male rats. Zargooshnia, Somayeh; Shahidi, Siamak; Ghahremanitamadon, Fatemeh; Nikkhah, Ali; Mehdizadeh, Mehdi; Soleimani Asl, Sara // Metabolic Brain Disease;Feb2015, Vol. 30 Issue 1, p151 

    Alzheimer's disease (AD) begins with impairment in synaptic functions before developing into later neurodegeneration and neural loss. In the present study we have examined the protective effects of Borago Officinalis (borage) extract on amyloid β (Aβ)-Induced long term potentiation (LTP)...

  • Phagocytic cells as a contributor to In Vivo degradation of alkyl mercury. Suda, Ikuo; Suda, Mari; Hirayama, Kimiko // Bulletin of Environmental Contamination & Toxicology;Sep1993, Vol. 51 Issue 3, p394 

    The article presents a study which investigates the three contributions of phatocytic cells to in vivo alkyl degradation. The study measures the degradation ability of phatocytic cells in vitro polymorphonuclear leukocytes (PMN), macrophages, and mononuclear leukocytes (MNL) in rats. The result...

  • Comparative study on some immunological traits in two different genetic groups of chicken. El-Safty, Salah Abdel Rahman // Veterinary World;Nov2012, Vol. 5 Issue 11, p645 

    Aim: This study was carried out on one hundred and twenty chicks (60 Libyan native and 60 broiler chicks) to evaluate and compare some productive and immunological characteristics. Materials and Methods:Weekly body weight (from day-old until 6 weeks of age), feed conversion ratio (from 3- 6...

  • Modulation of Phagocytosis in Tetrahymena thermophila by Histamine and the Antihistamine Diphenhydramine. BUDUMA, Nikhil; BALABANIAN, Jenny; DALVI, Pranati; CHIA, Soo-Khee; DHALIWAL, Ashreet; ELIYA, Dany; BOOTHBY, John; BROS-SEEMANN, Shannon; KIBLER, Ruthann; KHURI, Sami; VEREGGE, Sally // Acta Protozoologica;2013, Vol. 52 Issue 4, p317 

    Histamine is a significant biological compound because of its role in mediating the human allergic and inflammatory pathways. Antihistamines are often administered to control the irritating symptoms of allergic reactions. We evaluated phagocytosis in the protist Tetrahymena thermophila for use...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics