TITLE

Susceptibility of fungi isolated from the respiratory tract of falcons to amphotericin B, itraconazole and voriconazole

AUTHOR(S)
Silvanose, C. D.; Bailey, T. A.; Di Somma, A.
PUB. DATE
August 2006
SOURCE
Veterinary Record: Journal of the British Veterinary Association;8/26/2006, Vol. 159 Issue 9, p282
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The minimum inhibitory concentrations (MICs) of fungi isolated from the air sacs of falcons before (group 1), and during antifungal treatment with amphotericin B nebulisation and oral itraconazole or voriconazole (group 2), or with itraconazole alone (group 3) or voriconazole alone (group 4) were determined. Before treatment, 95 per cent of the isolates, including Aspergillus fumigatus, Aspergilus flavus, Aspergillus niger and Aspergillus terreus, were susceptible to voriconazole at MICs up to 0·38 μg/mI, and all the isolates were susceptible at MICs up to μg/ml. Before treatment, 21 per cent of the isolates, including A fumigatus (27·6 per cent), A flavus (16·6 per cent), A niger (100 per cent) and A terreus (23 per cent), were resistant (MIC≥ μg/mI) to itraconazole; 51 per cent of the isolates, including A fumIgatus (31 per cent), A flavus (78 per cent), A niger (14 per cent) and A terreus (77 per cent), had MICs of over 1 μg/mI to amphotericin B, and after treatment their MICs increased significantly. In contrast, there were no significant differences between the MICs of voriconazole and itraconazole for the different Aspergillus species before and during treatment with these antifungal agents.
ACCESSION #
22382524

 

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