Effects of ingesting a high-fat diet upon exercise-training cessation on fat accretion in the liver and adipose tissue of rats

Paquette, Amélie; Charbonneau, Alexandre; Gauthier, Marie-Soleil; Savard, Roland; Lavoie, Jean-Marc; Yasari, Siham
August 2006
Applied Physiology, Nutrition & Metabolism;Aug2006, Vol. 31 Issue 4, p367
Academic Journal
The purpose of the present study was to determine if exercise trained rats might benefit from protection against fat accumulation in response to an obesity stimulus initiated upon training cessation. Two groups of female rats were either treadmill trained for 8 weeks (DTr) or remained sedentary (Sed). They were then submitted either to a high-fat diet (HF; 42 E%) or kept on a standard diet (SD; 12.5 E% lipids) for another 6 weeks while remaining sedentary. Fat accumulation in liver and adipocytes along with fat-cell diameter and plasma free fatty acid (FFA) levels were measured 0, 2, and 6 weeks after training cessation. Immediately after the training period (t = 0), DTr rats exhibited similar body mass and higher dietary intake but smaller body fat content (4 fat pads) compared with Sed rats. DTr rats, under both diets, exhibited higher gains in body fat than Sed rats (DTr vs. Sed, 71% vs. 8% and 132% vs. 55% for SD and HF, respectively), such that fat mass in all 4 depots was similar to Sed rats 6 weeks after training cessation. Despite higher adipocyte fat accretion, liver lipid infiltration was not increased in DTr animals and plasma FFA levels were lower throughout the detraining period. In addition, plasma leptin levels remained lower in DTr animals throughout the detraining period under the HF diet condition. The present results indicate that previously exercise trained rats are not protected against adipocyte fat accumulation whether they ingest a standard or a high-fat diet.


Related Articles

  • Adipose Tissue as an Endocrine Organ. Sadovsky, Richard // American Family Physician;3/1/2005, Vol. 71 Issue 5, p989 

    Discusses research being done on adipose tissue. Reference to a study by E. E. Kershaw et al, published in a June 2004 issue of the "Journal of Clinical Endocrinology & Metabolism"; Association of adipose tissue with obesity; Endocrine effects of leptin, a polypeptide produced by adipocytes.

  • T1:03 Adipocyte differetiation and secretion.  // International Journal of Obesity & Related Metabolic Disorders;May2003 Supplement, Vol. 27, pS23 

    International Journal of Obesity (2003) 27, S23-S24. doi:10.1038/sj.ijo.0802345

  • Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Christiansen, T.; Richelsen, B.; Bruun, J.M. // International Journal of Obesity;Jan2005, Vol. 29 Issue 1, p146 

    BACKGROUND:: Obesity is associated with insulin resistance and premature atherosclerosis. The human adipose tissue produce several adipokines including monocyte chemoattractant protein (MCP)-1, associated with cardiovascular disease and found to be involved in the pathogenesis of atherosclerosis...

  • Adipose tissue growth and differentiation: view from the chair. Lau, D C W // International Journal of Obesity & Related Metabolic Disorders;Nov2000 Supplement, Vol. 24, pS20 

    Focuses on various researches related to the growth of adipose tissues and its differentiation that have been conducted since 1970. Ways in which expansion of adipose tissue mass can be accomplished in people suffering with obesity; Importance of the discovery of preadipocytes; Role of leptin...

  • Resolution of inflammation in obesity-induced liver disease. Rius, Bibiana; López-Vicario, Cristina; González-Périz, Ana; Morán-Salvador, Eva; García-Alonso, Verónica; Clària, Joan; Titos, Esther // Frontiers in Immunology;Aug2012, Vol. 3, p1 

    Low-grade inflammation in adipose tissue is recognized as a critical event in the development of obesity-related co-morbidities. This chronic inflammation is powerfully augmented through the infiltration of macrophages, which together with adipocytes, perpetuate a vicious cycle of inflammatory...

  • Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator-Activated Receptor γ Activation. Yao-Borengasser, Aiwei; Rasouli, Neda; Varina, Vijayalakshmi; Miles, Leslie M.; Phanavanh, Bounleut; Starks, Tasha N.; Phan, Jack; Spencer III, Horace J.; McGehee Jr., Robert E.; Reue, Karen; Kern, Philip A. // Diabetes;Oct2006, Vol. 55 Issue 10, p2811 

    Lipin-α and -β are the alternatively spliced gene products of the Lpin1 gene, whose product lipin is required for adipocyte differentiation. Lipin deficiency causes lipodystrophy, fatty liver, and insulin resistance in mice, whereas adipose tissue lipin overexpression results in increased...

  • From Blood Monocytes to Adipose Tissue-Resident Macrophages. Curat, Cyrile A.; Miranville, Alexandra; Sengenès, Coralie; Diehl, Michael; Tonus, Carolin; Busse, Rudi; Bouloumié, Arme // Diabetes;May2004, Vol. 53 Issue 5, p1285 

    Obesity has been suggested to be a low-grade systemic inflammatory state, therefore we studied the interaction between human adipocytes and monocytes via adipose tissue (AT)-derived capillary endothellum. Cells composing the stroma-vascular fraction (SVF) of human ATs were characterized by...

  • MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity. Huangming Xie; Lim, Bing; Lodish, Harvey F. // Diabetes;May2009, Vol. 58 Issue 5, p1050 

    OBJECTIVE--We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity. RESEARCH DESIGN AND METHODS--Using miRNA microarrays, we profiled the expression of >370 miRNAs during adipogenesis of preadipocyte 3T3-L1 cells and adipocytes from leptin...

  • Loss of the TNFα function inhibits Wnt/β-catenin signaling, exacerbates obesity development in adolescent spontaneous obese mice. Gong, Maolei; Liu, Chuanguo; Zhang, Liang; Zhang, Hongbin; Pan, Jie // Molecular & Cellular Biochemistry;Jun2014, Vol. 391 Issue 1/2, p59 

    Tumor necrosis factor alpha (TNFα) is an adipokine involved in the regulation of cell differentiation and lipid metabolism, but its specific role has not been clearly understood. We validated a hypothesis that loss of TNFα function would inhibit Wnt/β-catenin signaling and accelerate...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics