Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

Vulliemoz, S.; Lurati-Ruiz, F.; Borruat, F.-X.; Delavelle, J.; Koralnik, I. J.; Kuntzer, I.; Bogousslavsky, J.; Picard, F.; Landis, T.; Du Pasquier, R. A.
September 2006
Journal of Neurology, Neurosurgery & Psychiatry;Sep2006, Vol. 77 Issue 9, p1079
Academic Journal
Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCY), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.


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