TITLE

Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

AUTHOR(S)
Vulliemoz, S.; Lurati-Ruiz, F.; Borruat, F.-X.; Delavelle, J.; Koralnik, I. J.; Kuntzer, I.; Bogousslavsky, J.; Picard, F.; Landis, T.; Du Pasquier, R. A.
PUB. DATE
September 2006
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Sep2006, Vol. 77 Issue 9, p1079
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCY), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.
ACCESSION #
22312764

 

Related Articles

  • Etanercept.  // Reactions Weekly;3/21/2009, Issue 1244, p17 

    The article describes the case of a 46-year-old woman who developed necrotising fasciitis while under etanercept treatment regimen for refractory dermatomyositis. The patient has been receiving immunosuppressants such as methotrexate, prednisolone, azathioprine and cyclophosphamide. Because her...

  • Rituximab as a first-line agent for the treatment of dermatomyositis. Haroon, Muhammad; Devlin, Joe // Rheumatology International;Jun2012, Vol. 32 Issue 6, p1783 

    B cells may play a pivotal role in the pathophysiology of DM, and reports have claimed that targeting B cells is a viable treatment option in patients with dermatomyositis. A 20-year-old girl presented in October 2007, with few weeks' history of proximal muscle weakness. Gottron's papules were...

  • Ciclosporin.  // Reactions Weekly;4/26/2008, Issue 1199, p16 

    The article describes the case of a male renal transplant recipient who developed a fatal cutaneous squamous cell cancer (SCC) during immunosuppressive treatment with ciclosporin. The patient started to receive ciclosporin 5 milligram per kilogram after a renal transplantation in 1989 at the age...

  • Early Treatment Is Best for Long-Term Outcome of Juvenile Dermatomyositis. Gorgos, Diana // Dermatology Nursing;Oct2004, Vol. 16 Issue 5, p461 

    The article reports the findings of a study published in the May 2004 issue of the journal "Dermatology Times," which diagnosed the outcome of juvenile dermatomyositis. The study suggests that the timely diagnosis of juvenile dermatomyositis is important because the best method for preventing...

  • Long-term outcome of juvenile dermatomyositis rests on early treatment with immunosuppresants. Guttman, Cheryl // Dermatology Times;May2004, Vol. 25 Issue 5, p35 

    Focuses on the efficacy of immunosuppressive agents in managing juvenile dermatomyositis to prevent calcinosis. Overall mortality rate associated with dermamyositis in children; Means of minimizing the risk of the disease development; Application of a number of medications to treat existing...

  • The impact of F-FDG PET on the management of patients with suspected large vessel vasculitis. Fuchs, Martin; Briel, Matthias; Daikeler, Thomas; Walker, Ulrich; Rasch, Helmut; Berg, Scott; Ng, Quinn; Raatz, Heike; Jayne, David; Kötter, Ina; Blockmans, Daniel; Cid, Maria; Prieto-González, Sergio; Lamprecht, Peter; Salvarani, Carlo; Karageorgaki, Zaharenia; Watts, Richard; Luqmani, Raashid; Müller-Brand, Jan; Tyndall, Alan // European Journal of Nuclear Medicine & Molecular Imaging;Feb2012, Vol. 39 Issue 2, p344 

    Purpose: We aimed to assess the impact of F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the management of patients with suspected large vessel vasculitis. Methods: An international expert panel determined diagnoses and clinical management in patients with suspected large...

  • Efficacy of Steroid Pulse Therapy in Combination with Mizoribine Following Tonsillectomy for Immunoglobulin A Nephropathy in Renally Impaired Patients. Kaneko, Tomohiro; Shimizu, Akira; Tsuruoka, Shuichi; Iino, Yasuhiko; Katayama, Yasuo // Journal of Nippon Medical School;2013, Vol. 80 Issue 4, p279 

    Background: The long-term prognosis of immunoglobulin A nephropathy is poor. Treatment is intended to achieve complete remission in the early stage or to preserve renal function in the advanced stages. In Japan, aggressive steroid pulse therapy following tonsillectomy (tonsillectomy-pulse...

  • Immunosuppressants.  // Reactions Weekly;10/11/2008, Issue 1223, p17 

    The article presents the case of a 44-year old man who developed post-transplant lymphoproliferative disorder (PTLD) after receiving immunosuppressants. The immunosuppressants were basiliximab, azathioprine, tacrolimus, prednisolone, mycophenolate mofetil, and methylprednisolone. The patient...

  • Azathioprine/tacrolimus.  // Reactions Weekly;7/18/2009, Issue 1261, p7 

    The article describes the case of a 43-year-old renal transplant recipient who developed cholestatic hepatitis while receiving treatment with azathioprine and tacrolimus. Particular focus is given to her medical history, along with her concomitant medications. The results of her laboratory...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics