TITLE

Occupational exposure to organic solvent mixtures during pregnancy and the risk of non-syndromic oral clefts

AUTHOR(S)
Chevrier, C.; Dananché, B.; Bahuau, M.; Nelva, A.; Herman, C.; Francannet, C.; Robert-Gnansia, E.; Cordier, S
PUB. DATE
September 2006
SOURCE
Occupational & Environmental Medicine;Sep2006, Vol. 63 Issue 9, p617
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To examine the association between maternal occupational exposure to mixtures of organic solvents during pregnancy and the risk of non-syndromic oral clefts. Methods: A case-control study (164 cleft lip with/without cleft palate (CLIP), 76 cleft palate (CP), 236 controls) was conducted in France to investigate the role of maternal occupational exposure to organic solvents at the beginning of pregnancy in the risk of non-syndromic oral clefts. An expert chemist, guided by a detailed description of the women's occupational tasks, assessed exposure for each. Analysis of the findings used logistic regression. Results: In the control group, 39% of the women who reported working during pregnancy were exposed to at least one type of organic solvent. The risk of oral clefts was associated with oxygenated (for CL/P: OR= 1.8, 95% Cl 1.1 to 2.9; and for CP, OR= 1.4, 95% Cl 0.7 to 2.7), chlorinated (OR= 9.4, 95% Cl 2.5 to 35.3; OR=3.8, 95% Cl 0.7 to 20.7), and petroleum (OR=3.6, 95% Cl 1.5 to 8.8; OR= 1.2, 95% Cl 0.3 to 4.9) solvents. The risk of oral clefts increased linearly with level of exposure within the three subgroups of oxygenated solvents we considered (aliphatic alcohols, glycol ethers, and other oxygenated solvents, including esters, ketones, and aliphatic aldehydes). Conclusions: Results suggest that maternal occupational exposure to organic solvents during pregnancy may play a role in the aetiology of oral clefts. The limited number of subjects and the problem of multiple exposures require that these results be interpreted cautiously.
ACCESSION #
22291026

 

Related Articles

  • Primary Alcohols, Aldehydes and Ester Transformations into Ketones over Oxide Catalysts. Klimkiewicz, R. // Polish Journal of Environmental Studies;2008, Vol. 17 Issue 5, p727 

    This paper presents the suitability of the unpopular bimolecular reaction of primary alcohol condensation to ketones as the management method for waste or excessive materials containing primary alcohols, aldehydes and esters. This method simultaneously allows winning non symmetric or long-chain...

  • Microbial formation of esters. Park, Yong Cheol; Shaffer, Catherine Emily Horton; Bennett, George N. // Applied Microbiology & Biotechnology;Nov2009, Vol. 85 Issue 1, p13 

    Small aliphatic esters are important natural flavor and fragrance compounds and have numerous uses as solvents and as chemical intermediates. Besides the chemical or lipase-catalyzed formation of esters from alcohols and organic acids, small volatile esters are made by several biochemical routes...

  • Application of Zr-Mg-Y-O Catalyst for Ketonization of Ester and Alcohol Type Industrial Wastes. Klimkiewicz, R.; Grabowska, H.; Teterycz, H. // Polish Journal of Environmental Studies;2003, Vol. 12 Issue 1, p67 

    Aldehydes and their derivatives - primary alcohols and esters undergo ketonization in the gas phase in the range of 350-450 °C over multicomponental oxide catalyst - Zr-Mg-Y-O. This method is appropriate for processing mixtures of components. An experimental study was performed on...

  • Synthesis of o-nitrosoacylbenzenes from o-nitrobenzyl alcohols and their derivatives. Gazzaeva, R.; Fedotov, A.; Trofimova, E.; Popova, O.; Mochalov, S.; Zefirov, N. // Russian Journal of Organic Chemistry;Jan2006, Vol. 42 Issue 1, p87 

    Nitration of substituted benzyl alcohols, as well as ethers and esters derived therefrom, with nitric acid in acetic anhydride was studied. The corresponding o-nitrobenzyl alcohols and their derivatives formed as the primary products are capable of being converted into o-nitrosoacylbenzenes by...

  • Lignin-type, α,β-unsaturated aldehydes of lignin-type in organic solvents. Moiseev, D.; James, B.; Gushchin, A. // Russian Journal of General Chemistry;May2012, Vol. 82 Issue 5, p840 

    A 1:1 reaction of [HO(CH)]P with 4-hydroxy-3-methoxy-cinnamaldehyde (coniferaldehyde) or 3,5-dimethoxy-4-hydroxycinnamaldehyde (sinapaldehyde) in acetone at room temperature affords phosphonium zwitterions of the type RPCH(4-O-Ar)CHCHO; other phosphines [R = Et, n-Bu, (CH)CN, and p-Tol] do not...

  • News from European Institutions and Associations.  // European Food & Feed Law Review;2008, Vol. 3 Issue 6, p422 

    The article offers information on the evaluation of several health claims by the European Food Safety Authority (EFSA). It is stated that EFSA has evaluated several claims made by several institutions and associations of Europe. Consideration of benzyl derivatives which were claimed to be...

  • Volatiles in flowers of Viburnum odoratissimum. Wei, Jin-Feng; Yin, Zhen-Hua; Kang, Wen-Yi // Chemistry of Natural Compounds;Mar2013, Vol. 49 Issue 1, p154 

    The article presents a study which described the chemical composition of volatiles extracted from the flowers of Viburnum odoratissimum. Headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GS-MS) yielded esters, alkanes, ketones, alcohols, aldehydes and...

  • Selective hydrogenation of α,β-unsaturated carbonyl compounds on supported Ru-Sn catalysts. Špringerová, Jana; Kačer, Petr; Červený, Libor // Research on Chemical Intermediates;2005, Vol. 31 Issue 9, p785 

    Selective catalytic hydrogenation of unsaturated carbonylic compounds to unsaturated alcohols on bi-metallic Ru-Sn catalysts/support was studied. The catalysts were prepared by the sol–gel method and the method of co-impregnation with the objective to evaluate selected parameters of...

  • An efficient procedure for the TEMPO-catalyzed oxidation of alcohols to aldehydes and ketones using ferric chloride hexahydrate as terminal oxidant. Kumar, R. Senthil; Karthikeyan, K.; Perumal, Paramasivan T. // Canadian Journal of Chemistry;Jul2008, Vol. 86 Issue 7, p720 

    A simple, efficient procedure for the oxidation of alcohols by catalytic 2,2,6,6-tetramethyl-piperidyl-1-oxy (TEMPO) was developed using FeCl3·6H2O as the terminal oxidant. The reaction gives high yield of the corresponding aldehydes and ketones with no over oxidation to the acid.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics