TITLE

Occupational trichloroethylene exposure and non-Hodgkin's lymphoma: a meta-analysis and review

AUTHOR(S)
Mandel, J. H.; Kelsh, M. A.; Mink, P. J.; Alexander, D. D.; Kalmes, R. M.; Weingart, M.; Yost, I.; Goodman, M.
PUB. DATE
September 2006
SOURCE
Occupational & Environmental Medicine;Sep2006, Vol. 63 Issue 9, p597
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Methods: Meta-analysis and review of 14 occupational cohort and four case-control studies of workers exposed to trichloroethylene (ICE) to investigate the relation between ICE exposure and the risk of non- Hodgkin's lymphoma (NHL). Studies were selected and categorised based on a priori criteria, and results from random effects meta-analyses are presented. Results: The summary relative risk estimates (SRRE) for the group of cohort studies that had more detailed information on TCE exposure was 1 .29 (95% Cl 1 .00 to 1 .66) for the total cohort and 1 .59 (95% Cl 1 .21 to 2.08) for the seven studies that identified a specific ICE exposed sub-cohort. SRREs for three studies with cumulative exposure information were 1 .8 (95% CI 0.62 to 5.26) for the lowest exposure category and 1 .41 (95% Cl 0.61 to 3.23) for the highest category. Comparison of SRREs by levels of TCE exposure did not indicate exposure-response trends. The remaining cohort studies that identified ICE exposure but lacked detailed exposure information had an SRRE of 0.843 (95% Cl 0.72 to 0.98). Case-control studies had an SRRE of 1.39 (95% Cl 0.62 to 3.10). Statistically significant findings for the Group 1 studies were driven by the results from the subgroup of multiple industry cohort studies (conducted in Europe) (SRRE = 1 .86; 95% Cl 1 .27 to 2.71). The SRRE for single industry cohort studies was not significantly elevated (SRRE= 1.25; 95% Cl 0.87 to 1.79). Conclusions: Interpretation of overall findings is hampered by variability in results across the Group 1 studies, limited exposure assessments, lack of evidence of exposure response trends, lack of supportive information from toxicological and mechanistic data, and absence of consistent findings in epidemiologic studies of exposure and NHL. Although a modest positive association was found in the ICE sub-cohort analysis, a finding attributable to studies that included workers from multiple industries, there is insufficient evidence to suggest a causal link between ICE exposure and NHL.
ACCESSION #
22291024

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics