PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial

Voskuijl, W.; de Lorijn, F.; Verwijs, W.; Hogeman, P.; Heijmans, J.; Mäkel, W.; Taminiau, J.; Benninga, M.
November 2004
Gut;Nov2004, Vol. 53 Issue 11, p1590
Academic Journal
Background: Recently, polyethylene glycol (PEG 3350) has been suggested as a good alternative laxative to lactulose as a treatment option in paediatric constipation. However, no large randomised controlled trials exist evaluating the efficacy of either laxative. Aims: To compare PEG 3350 (Transipeg: polyethylene glycol with electrolytes) with lactulose in paediatric constipation and evaluate clinical efficacy/side effects. Patients: One hundred patients (aged 6 months-15 years) with paediatric constipation were included in an eight week double blinded, randomised, controlled trial. Methods: After faecal disimpaction, patients <6 years of age received PEG 3350 (2.95 g/sachet) or lactulose (6 g/sachet) while children ⩾6 years started with 2 sachets/day. Primary outcome measures were: defecation and encopresis frequency/week and successful treatment after eight weeks. Success was defined as a defecation frequency ⩾3/week and encopresis (1 every two weeks. Secondary outcome measures were side effects after eight weeks of treatment. Results: A total of 91 patients (49 male) completed the study. A significant increase in defecation frequency (PEG 3350: 3 pre v 7 post treatment/week; lactulose: 3 pre v 6 post/week) and a significant decrease in encopresis frequency (PEG 3350: 10 pre v 3 post/week; lactulose: 8 pre v 3 post/week) was found in both groups (NS). However, success was significantly higher in the PEG group (56%) compared with the lactulose group (29%). PEG 3350 patients reported less abdominal pain, straining, and pain at defecation than children using lactulose. However, bad taste was reported significantly more often in the PEG group. Conclusions: PEG 3350 (0.26 (0.11) g/kg), compared with lactulose (0.66 (0.32) g/kg), provided a higher success rate with fewer side effects. PEG 3350 should be the laxative of first choice in childhood constipation.


Related Articles

  • Comparison of Polyethylene Glycol 3350 and Lactulose for Treatment of Chronic Constipation of Children. Gremse, David A.; Hixon, Jamie; Crutchfield, Alysia // Clinical Pediatrics;May2002, Vol. 41 Issue 4, p225 

    Presents a study that compared the efficacy of polyethylene glycol (PEG) 3350 and lactulose in the treatment of chronic constipation in children. Background on the occurrence of chronic constipation in children; Information on the treatment of functional constipation in children; Effect of PEG...

  • Fonksiyonel kabızlığı olan çocuklarda probiyotik ve laktuloz tedavilerinin etkinliÄŸinin karşılaÅŸtırılması ve kabızlık tedavisinin yaÅŸam kalitesi üzerine olan etkisinin deÄŸerlendirilmesi Olgaç, M. Asburçe B.; Balcı Sezer, Oya; Özçay, Figen // Cocuk Sagligi ve Hastaliklari Dergisi;ock-mar2013, Vol. 56 Issue 1, p1 

    Olgaç MAB, Balcı Sezer O, Özçay F. (Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey). Comparison of probiotic and lactulose treatments in children with functional constipation and determination of the effects of constipation treatment on quality...

  • Long-term Efficacy of Polyethylene Glycol 3350 for the Treatment of Chronic Constipation in Children with and without Encopresis. Pashankar, Dinesh S.; Bishop, Warren P.; Loening-Baucke, Vera // Clinical Pediatrics;Nov/Dec2003, Vol. 42 Issue 9, p815 

    Seventy-four children (43 with chronic constipation, 31 with constipation and encopresis) treated with polyethylene glycol 3350 (PEG) for longer than 3 months were studied to assess long-term efficacy. The mean duration of PEG therapy was 8.4 months (range, 3-30). Weekly stool frequency, stool...

  • PEG 3350 vs. Lactulose for Constipation in Children. Ebell, Mark // American Family Physician;5/15/2005, Vol. 71 Issue 10, p1987 

    Discusses research being done on the effectiveness of polyethylene glycol 3350 and lactulose as a treatment for functional constipation in children. Reference to a study by W. Voskuijl et al published in the November 2004 issue of "Gut"; Dosage of osmotic laxatives given to subjects; Frequency...

  • Diagnosis and management of idiopathic childhood constipation: summary of NICE guidance. Bardisa-Ezcurra, Lauren; Ullman, Roz; Gordon, Jenny // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;6/5/2010, Vol. 340 Issue 7758, p1240 

    The article focuses on the recommendations of the National Institute for Health and Clinical Excellence (NICE) for the diagnosis and clinical management of children and young people with idiopathic constipation in Great Britain. It describes the clinical features that indicate constipation. The...

  • A case of aspartate aminotransferase macroenzyme. Cabrera-Abreu, J.; Jain, R.; Robinson, P.; Edees, S.; Staughton, T. // Annals of Clinical Biochemistry;May2008, Vol. 45 Issue 3, p320 

    Aspartate aminotransferase (AST) macroenzyme can result in elevated AST activity in patients with no disease. This case report describes a six-year-old boy who presented to his family doctor with a history of chronic constipation and lower back pain. Routine blood tests showed normal creatine...

  • No-Enema Therapy for Idiopathic Constipation and Encopresis. Gleghorn, Elizabeth E.; Heyman, Melvin B.; Rudolph, Colin D. // Clinical Pediatrics;Dec1991, Vol. 30 Issue 12, p669 

    Idiopathic constipation and encopresis of childhood are thought to occur when children volitionally withhold stool. Withholding may be prompted by social pressures or by episodes of painful defecation. Repetitive withholding may result in colonic dilatation and colorectal dysfunction. Therapy...

  • Reinforcement of Incontinent Stools in the Treatment of Encopresis. Piazza, Cathleen C.; Fisher, Wayne; Chinn, Shawn; Bowman, Lynn // Clinical Pediatrics;Jan1991, Vol. 30 Issue 1, p28 

    In this paper, fecal incontinence and constipation were treated in two mentally retarded individuals using a novel intervention wherein incontinent stools were first rewarded in order to increase the frequency of bowel movements. This intervention was implemented only after more traditional...

  • Çocukluk çağı kabızlığında elektrolit içeren polietilen glikol kullanımı. Önal, Zerrin; Usta, Merve; Doğan, Yaşar; Kutlu, Tufan; Çokuğraş, Fügen Çullu; Erkan, Tülay // Turkish Pediatrics Archive / Turk Pediatri Arsivi;2008, Vol. 43 Issue 4, p135 

    Aim: To investigate the effectiveness and safety of polyethylene glycol (PEG 3350) as a therapy in children after the age of one year. Material and Method: The study included 50 cases, aged between 1-12 years. All of the cases were prescribed PEG 3350. We aimed one or two painless soft bowel...


Read the Article


Sign out of this library

Other Topics