TITLE

Deranged smooth muscle a-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series

AUTHOR(S)
Knowles, C. H.; Silk, D. B. A.; Darzi, A.; Veress, B.; Feakins, R.; Raimundo, A. H.; Crompton, T.; Browning, E. C.; Lindberg, G.; Martin, J. E.
PUB. DATE
November 2004
SOURCE
Gut;Nov2004, Vol. 53 Issue 11, p1583
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: Chronic idiopathic intestinal pseudo-obstruction (CIIP) is a severe motility disorder associated with significant morbidity. Several histopathological (neuropathic and myopathic) phenotypes have been described but only a single adult with jejunal smooth (circular) muscle α-actin deficiency. We present a prospective multinational case series investigating smooth muscle α-actin deficiency as a biomarker of this disease. Methods: A total of 115 fully clinically and physiologically (including prolonged (24 hour) ambulatory jejunal manometry) characterised CIIP patients from three European centres were studied. Immunohistochemical localisation of actins and other cytoskeletal proteins were performed on laparoscopic full thickness jejunal biopsies and compared with adult controls. Distribution of α-actin was also characterised in other gut regions and in the developing human alimentary tract. Results: Twenty eight of 115 (24%) CIIP patient biopsies had absent (n = 22) or partial (n = 6) jejunal smooth muscle α-actin immunostaining in the circular muscle layer. In contrast, smooth muscle α-actin staining was preserved in the longitudinal muscle and in adult jejunal controls (n = 20). Comparative study of other adult alimentary tract regions and fetal small intestine, suggested significant spatial and temporal variations in smooth muscle α-actin expression. Conclusions: The ability to modulate α-smooth muscle actin expression, evident in development, is maintained in adult life and may be influenced by disease, rendering it a valuable biomarker even in the absence of other structural abnormalities.
ACCESSION #
22269072

 

Related Articles

  • Outcome of alimentary tract duplications operated on by minimally invasive surgery: a retrospective multicenter study by the GECI (Groupe d'Etude en Coeliochirurgie Infantile). Guérin, Florent; Podevin, Guillaume; Petit, Thierry; Lopez, Manuel; Lagausie, Pascal; Lardy, Hubert; Bonnard, Arnaud; Becmeur, François; Philippe, Paul; Larroquet, Michèle; Sapin, Emmanuel; Kurzenne, Jean; Mandat, Aurélie; Francois-Fiquet, Caroline; Gaudin, Jean; Valioulis, Ioannis; Morisson-Lacombe, Gérard; Montupet, Philippe; Demarche, Martine // Surgical Endoscopy;Oct2012, Vol. 26 Issue 10, p2848 

    Background: Alimentary tract duplications (ATD) are a rare cause of intestinal obstruction in childhood. There are many case reports but few series about laparoscopy or thoracoscopy for ATD. The aim of our study was to report the outcome of minimally invasive surgery (MIS) for ATD. Methods: This...

  • Small-bowel obstruction associated with Crohn's enterolith. Tewari, Anuj; Weiden, Jason; Johnson, Jamlik-Omari // Emergency Radiology;Aug2013, Vol. 20 Issue 4, p341 

    One of the lesser known clinical manifestations of Crohn's disease is the formation of small-bowel enteroliths. These concretions precipitate in the setting of small-bowel stasis within the alimentary tract and are associated with a variety of disease states causing strictures or diverticula. In...

  • Acute Small Bowel Obstruction Due to Meckel's Diverticulum Forming a Knot around the Ileum: An Unusual Presentation. Nadkarni, Akshay; Shetty, Prashanth; Bhandary, Siddharth; Jain, Rohit; Rao, B. H. Anand // Internet Journal of Surgery;2008, Vol. 17 Issue 2, p13 

    Small-bowel obstruction that accounts for 20% of causes of intestinal obstruction may be due to many causes and Meckel's diverticulum as a cause is rare. We present a 70-year-old man who presented with symptoms of acute intestinal obstruction. Examination revealed central abdominal distension...

  • Laparoscopic management of acute small bowel obstruction. Kirshtein, B.; Roy-Shapira, A.; Lantsberg, L.; Avinoach, E.; Mizrahi, S. // Surgical Endoscopy;Apr2005, Vol. 19 Issue 4, p464 

    Background: As minimally invasive surgery gains ground, it is entering realms previously considered to be relative contraindications for laparoscopy. We reviewed our experience with the laparoscopic approach to the management of small bowel obstruction (SBO). Methods: From December 1997 to ...

  • Staged and complete laparoscopic management of cholelithiasis in a patient with gallstone ileus and bile duct calculi. El-Dhuwaib, Y.; Ammori, B.J. // Surgical Endoscopy;Jun2003, Vol. 17 Issue 6, p988 

    Background: Gallstone ileus is an uncommon cause of small bowel obstruction, and its incidence peaks in elderly women. Although enterolithotomy has been accomplished laparoscopically, often using a laparoscopically assisted approach, controversy persists as to the indication, timing, and...

  • Multiple simultaneous small bowel intussusceptions in an adult. Varban, Oliver; Tavakkoli, Ali // Journal of Surgical Case Reports;Nov2012, Vol. 2012 Issue 11, p1 

    Intestinal intussusception is a rare cause of bowel obstruction in adults and can be associated with a pathologic lead point. We report a case of multiple simultaneous small bowel intussusceptions in a 41-year-old female who presented with a 3-week history of intermittent, crampy epigastric...

  • Predictors of Failure of the Laparoscopic Approach for the Management of Small Bowel Obstruction. QURESHI, IRFAN; AWAD, ZIAT T. // American Surgeon;Sep2010, Vol. 76 Issue 9, p947 

    Small bowel obstruction (SBO) is a common cause of hospital admission. Our objective is to determine variables that correlate with failure of the laparoscopic approach for SBO. Twenty-three consecutive patients underwent diagnostic laparoscopy with curative intent for treatment of SBO by a...

  • Small bowel incarceration in a broad ligament defect. Guillem, P.; Cordonnier, C.; Bounoua, F.; Adams, P.; Duval, G. // Surgical Endoscopy;Jan2003, Vol. 17 Issue 1, p161 

    We report the case of a 33-year-old woman whose medical history included three normal pregnancies without previous abdominal or pelvic surgery. She presented with small bowel obstruction. An abdominal computed tomography (CT) scan study revealed air fluid levels in the pelvis. Laparoscopic...

  • Partial small bowel obstruction: clinical issues and recent technical advances. Kendrick, Michael L. // Abdominal Imaging;May/Jun2009, Vol. 34 Issue 3, p329 

    Mechanical small bowel obstruction (SBO) remains a common clinical problem despite ever-increasing medical and surgical advances. The predominant etiology continues to be postoperative adhesions, accounting for approximately two-thirds of all obstructive events. As opposed to high-grade or...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics