Advances in our understanding of the pathology of chronic intestinal pseusdo-obstruction

De Giorgio, R.; Sarnelli, G.; Corinaldesi, R.; Stanghellini, V.
November 2004
Gut;Nov2004, Vol. 53 Issue 11, p1549
Academic Journal
Chronic intestinal pseudo-obstruction (CIP) represents a particularly difficult clinical challenge. It is a rare and highly morbid syndrome characterised by impaired gastrointestinal propulsion together with symptoms and signs of bowel obstruction in the absence of any lesions occluding the gut lumen. CIP can be classified as either ‘secondary’ to a wide array of recognised pathological conditions or ‘idiopathic’ (CIIP). This review will focus on CIIP, and specifically on the underlying pathological abnormalities. Combined clinical and histopathological studies are needed to highlight new perspectives in the understanding and management of chronic intestinal pseudo-obstruction.


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