TITLE

Prospective evaluation of fluorouracil chemotherapy based on the genetic makeup of colorectal cancer

AUTHOR(S)
Carethers, J. M.
PUB. DATE
June 2006
SOURCE
Gut;Jun2006, Vol. 55 Issue 6, p759
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article analyzes the use of 5-fluorouracil (5-FU) chemotherapy for treating patients afflicted with mismatch repair (MMR) proficient and MMR deficient colorectal cancer. After analyzing hereditary non-polyposis colorectal cancer in which a germline mutation occurs in genes that encode proteins for DNA mismatch repair (MMR), it was discovered that around 15% of sporadic colorectal cancers lack intact MMR due to the epigenetic inactivation of the MMR protein hMLI without genetic mutation. Patients with MMR proficient tumors are said to have a more favorable prognosis for survival than those with MMR deficient tumors. It is reported that the genetic makeup of the tumor may predict the response to 5-FU, as patients with MMR proficient tumors gain survival with 5-FU treatment.
ACCESSION #
22212735

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics