The putative role of endogenous and exogenous opiates in inflammatory bowel disease

Collins, S.; Verma-Gandhu, M.
June 2006
Gut;Jun2006, Vol. 55 Issue 6, p756
Academic Journal
The article examines the role of endogenous and exogenous opiates in inflammatory bowel diseases (IBD). The upregulation of mu opioid receptors (MOR) in inflamed tissue from patients with Crohn's disease and ulcerative colitis was investigated and the upregulation to lamina propria mononuclear cells was partly localized. It was found that the nervous system modulated intestinal inflammation via MOR regulation of cytokine production by lymphocytes. It was observed that motility in the colon is altered in patients with ulcerative colitis, and that the colon is particularly sensitive to the effects of opiates during active colitis, with a propensity for the generation of non-segmenting contractions.


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