Designing Spiegelmers to antagonise ghrelin

Hornby, P. J.
June 2006
Gut;Jun2006, Vol. 55 Issue 6, p754
Academic Journal
The article analyzes the designing and use of spiegelmers to interfere with the action of ghrelin, a 28 amino acid peptide localized immunocytochemically in parietal cells of the human stomach. In a study, the Spiegelmer NOX-B11 was injected intravenously 12 hours prior to administration of the natural ligand ghrelin. NOX-B11 was found to be effective in reversing ghrelin stimulated feeding in less than four hours to a cumulative intake similar to controls treated with vehicle. However, the response to ghrelin alone in the control group was statistically significant only at the one hour period.


Related Articles

  • Molecular analysis and chromosomal assignment of the canine CALC-I/α-CGRP gene. Wende, Sonja; Krempler, Andrea; Breen, Matthew; Brunnberg, Leo; Brenig, Bertram // Mammalian Genome;Sep2000, Vol. 11 Issue 9, p736 

    We have isolated a recombinant phage harboring the canine CALC-I/α-CGRP gene. The gene spans a region of approx. 5.3 kb and consists of six exons with sizes ranging from 95 bp (exon 2) and 494 bp (exon 4). By alternative splicing, two transcripts with ORFs of 390 and 384 nt are generated....

  • Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats. Jun Wang; Chen Chen; Rui-Yuan Wang // Endocrine (1355008X);Apr2008, Vol. 33 Issue 1, p77 

    Abstract  This study aims to clarify the effects of exercise on levels of appetite regulatory hormones in plasma and hypothalamus of obese rats. Diet-induced obese rats undergo short- (40 min) and long-term (40 min, 5 days/week for 8 weeks) exercises. The rats ran at a speed of...

  • Ghrelin.  // Encyclopedic Reference of Molecular Pharmacology;2004, p403 

    A definition of the term "ghrelin" is presented. It refers to a 28 amino acid peptide predominantly produced by the stomach, with substantially lower amounts derived from bowel, pancreas, kidney, placenta, pituitary and hypothalamus. The peptide has a strong growth hormone-releasing activity. It...

  • Motilin.  // Encyclopedic Reference of Molecular Pharmacology;2004, p609 

    The article presents an encyclopedia entry for "motilin." It refers to the 22-amino acid peptide hormone secreted by the enterochromaffin cells of the small intestine, which has a profound effect on gastric motility by inducing contractions of the antrum and duodenum. It acts on a G-protein...

  • Insights into Structure-Activity Relationships of Somatostatin Analogs Containing Mesitylalanine. Martín-Gago, Pablo; Aragón, Eric; Gomez-Caminals, Marc; Fernández-Carneado, Jimena; Ramón, Rosario; Martin-Malpartida, Pau; Verdaguer, Xavier; López-Ruiz, Pilar; Colás, Begoña; Cortes, María Alicia; Ponsati, Berta; Macias, Maria J.; Riera, Antoni // Molecules;Dec2013, Vol. 18 Issue 12, p14564 

    The non-natural amino acid mesitylalanine (2,4,6-trimethyl-L-phenylalanine; Msa) has an electron-richer and a more conformationally restricted side-chain than that of its natural phenylalanine counterpart. Taking these properties into account, we have synthesized ten somatostatin analogs...

  • NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution. Andersson, August; Mäler, Lena // Journal of Biomolecular NMR;Oct2002, Vol. 24 Issue 2, p103 

    The structure and dynamics of the gastrointestinal peptide hormone motilin, consisting of 22 amino acid residues, have been studied in the presence of isotropic q=0.5 phospholipid bicelles. The NMR solution structure of the peptide in acidic bicelle solution was determined from 203 NOE-derived...

  • The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins. Graf, Laura; Webel, Rike; Wagner, Sabrina; Hamilton, Stuart T.; Rawlinson, William D.; Sticht, Heinrich; Marschall, Manfred // Viruses (1999-4915);Dec2013, Vol. 5 Issue 12, p3213 

    The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cyclins, including cyclin T1, which is the usual...

  • Ghrelin Mediates Anticipation to a Palatable Meal in Rats. Merkestein, Myrte; Brans, Maike A.D.; Luijendijk, Mieneke C.M.; de Jong, Johannes W.; Egecioglu, Emil; Dickson, Suzanne L.; Adan, Roger A.H. // Obesity (19307381);May2012, Vol. 20 Issue 5, p963 

    Food anticipatory activity (FAA) is displayed in rats when access to food is restricted to a specific time frame of their circadian phase, a behavior thought to reflect both hunger and the motivation to eat. Rats also display FAA in a feeding schedule with ad libitum access to normal chow, but...

  • Does Helicobacter pyloriattack ghrelin-producing cells? Suzuki, Hidekazu; Hibi, Toshifumi // Journal of Gastroenterology;Apr2005, Vol. 40 Issue 4, p437 

    This article reports that ghrelin, a novel acylated endogenous ligand for the growth hormone secretagogue receptor, was isolated for the first time in 1999 at the National Cardiovascular Center Research Institute in Japan. It has since been reported that the circulating levels of ghrelin...


Read the Article


Sign out of this library

Other Topics