Designing Spiegelmers to antagonise ghrelin

Hornby, P. J.
June 2006
Gut;Jun2006, Vol. 55 Issue 6, p754
Academic Journal
The article analyzes the designing and use of spiegelmers to interfere with the action of ghrelin, a 28 amino acid peptide localized immunocytochemically in parietal cells of the human stomach. In a study, the Spiegelmer NOX-B11 was injected intravenously 12 hours prior to administration of the natural ligand ghrelin. NOX-B11 was found to be effective in reversing ghrelin stimulated feeding in less than four hours to a cumulative intake similar to controls treated with vehicle. However, the response to ghrelin alone in the control group was statistically significant only at the one hour period.


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