Postnatal weight increase and growth velocity of very low birthweight infants

Bertino, E.; Coscia, A.; Mombrà, M.; Boni, L.; Rossetti, G.; Fabris, C.; Spada, E.; Milani, S.
September 2006
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Sep2006, Vol. 91 Issue 5, pF349
Academic Journal
Background: Only a few studies have dealt with postnatal growth velocity of very low birthweight (VLBW) infants. Objective: To analyse weight growth kinetics of VLBW infants from birth to over 2 years of age. Patients: A total of 262 VLBW infants were selected; inaccurate estimate of gestational age, major congenital anomalies, necrotising enterocolitis, death, and loss to fallow up within the first year were the exclusion criteria. Methods: Body weight was recorded daily up to 28 days or up to discontinuation of parenteral nutrition, weekly up to discharge, then at 1, 3, 6, 9, 12, 18, and 24 months of corrected age. Individual growth profiles were fitted with a seven constant, exponential-logistic function suitable far modelling weight loss and weight recovery, two peaks, and the subsequent slow decrease in growth velocity. Results: After a postnatal weight loss, all infants showed a late neonatal peak of growth velocity between the 7th and 21st weeks; most also experienced an early neonatal peak between the 2nd and 6th week. VLBW infants who were small for gestational age and those with major morbidities grew less than reference VLBW infants who were the appropriate size for gestational age without major morbidities: at 2 years of age, the difference in weight was about 860 g. The more severe growth impairment seen in VLBW infants with major morbidities is' almost entirely due to the reduced height of the late neonatal peak of velocity. Conclusions: The growth model presented here should be a useful tool far evaluating to what extent different pathological conditions or nutritional and medical care protocols affect growth kinetics.


Related Articles

  • The Application of External Drainage from Intestinal Cavity in the Surgical Treatment for Neonates with Necrotizing Enterocolitis. Ji-xue Zhao; Chuan Zhang; Chun-yu Dong; Xue-song Zhao; Xin Fu // Applied Mechanics & Materials;2014, Issue 618, p388 

    Object: To explore the feasibility and effects of external drainage from intestinal cavity in the surgical treatment for the neonates with necrotizing enterocolitis. Methods: A retrospective analysis was conduct on 22 cases of newborns with extensive and multiple intestinal necrosis found...

  • Laparoscopy as an adjunct to peritoneal drainage in perforated necrotizing enterocolitis. Clark, Claire; Mackinlay, Gordon A. // Journal of Laparoendoscopic & Advanced Surgical Techniques;Aug2006, Vol. 16 Issue 4, p411 

    Intestinal perforation in very low birth weight infants with necrotizing enterocolitis has a high morbidity and mortality. We report the use of laparoscopy on day 30 of life in the treatment of a very low birth weight infant (900 g) with perforated necrotizing enterocolitis. The question of...

  • Combined use of alcohol hand rub and gloves reduces the incidence of late onset infection in very low birthweight infants. Ng, P C; Wong, H L; Lyon, D J; So, K W; Liu, F; Lam, R K Y; Wong, E; Cheng, A F B; Fok, T F // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jul2004, Vol. 89 Issue 4, pf336 

    Objective: To assess the incidence of late onset (> 72 hours) infection and necrotising enterocolitis (NEC) in very low birthweight (VLBW) infants in two 36 month periods using two hand hygiene protocols: conventional handwashing (HW; first 36 month period); an alcohol hand rub and gloves...

  • Conventional birth weight standards obscure fetal growth restriction in preterm infants. Cooke, Richard W. I. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2007, Vol. 92 Issue 3, pF189 

    Background and objective: It has been suggested that fetal growth restriction (FGR) is associated with fetal maturation so that, compared with appropriately grown preterm infants, mortality and some neonatal morbidities may be reduced. The evidence for this is conflicting, and severe FGR has...

  • Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Rees, Clare M.; Pierro, Agostino; Eaton, Simon // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2007, Vol. 92 Issue 3, pF193 

    Objectives: (1) To characterise neurodevelopmental outcome of neonates with necrotizing enterocolitis (NEC); (2) to define whether NEC increases risk of neurodevelopmental impairment in very low birth weight neonates; (3) to investigate whether stage of disease or need for surgery increase risk...

  • Enteral feeding for very low birth weight infants: reducing the risk of necrotising enterocolitis. Chauhan, M.; Henderson, G.; McGuire, W. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Mar2008, Vol. 93 Issue 2, pF162 

    The principal modifiable risk factors for necrotising enterocolitis (NEC) in very low birth weight infants relate to enteral feeding practices. Evidence exists that feeding with formula milk increases the risk of NEC. Currently, only limited data are available on the effect of the timing of feed...

  • Bovine Colostrum in Prevention of Necrotizing Enterocolitis and Sepsis in Very Low Birth Weight Neonates: A Randomized, Double-blind, Placebo-controlled Pilot Trial. Balachandran, Binesh; Dutta, Sourabh; Singh, Ramandeep; Prasad, Rajendra; Kumar, Praveen // Journal of Tropical Pediatrics;Feb2017, Vol. 63 Issue 1, p10 

    Objective: To study the efficacy of bovine colostrum in prevention of necrotizing enterocolitis (NEC) and sepsis in very low birth weight (VLBW) infants.Study Design: Randomized, double-blind, placebo-controlled pilot trial.Participants: Neonates with birth...

  • Nosocomial infection in small for gestational age newborns with birth weight <1500 g: a multicentre analysis. Bartels, Dorothee B.; Schwab, Frank; Geffers, Christine; Poets, Christian F.; Gastmeier, Pefra // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2007, Vol. 92 Issue 6, pF449 

    Objective: To investigate whether preterm newborns who are small for gestational age are at increased risk of nosocomial infections and necrotising enterocolitis. Design, setting and subjects: The German national surveillance system for nosocomial infection in very low birthweight infants uses...

  • Enteral feeding during packed red blood cell transfusion in English neonatal units. Parige, R.; Turner, C.; Sundaram, S.; Power, S. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Mar2014, Vol. 99 Issue 2, pF173 

    The article focuses on a study performed by researcher M. El-Dib on neonatal necrotising enterocolitis (NEC) which is associated with packed red blood cell transfusion (PRBCT). It mentions that risk factors for NEC include bacterial overgrowth, formula feeds, and rapid advancement of enternal...


Read the Article


Sign out of this library

Other Topics