TITLE

Characterization of an outbreak of tetM-containing Neisseria gonorrhoeae in Argentina

AUTHOR(S)
Cobo, M. Fernandez; Galarza, P.; Sparo, M.; Buscemi, L.; Pizarro, M. R.; Fiorito, S.
PUB. DATE
March 1999
SOURCE
International Journal of STD & AIDS;Mar1999, Vol. 10 Issue 3, p169
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Phenotypic and molecular characterization of an outbreak of 9 Neisseria gonorrhoeae (NG) isolates exhibiting high-level plasmid mediated resistance to penicillin and tetracycline (PP-TRNG) that took place in Tandil, Argentina between February and April 1995. Comparison with the patterns of the 3 PP-TRNG strains previously isolated were made. We determined the following markers for each strain: antimicrobial susceptibility, serogroup, auxotype, plasmid profile, presence of tet M determinant and restriction pattern of the tetM-containing plasmid. Antimicrobial tests values were: tetracycline disk diameter 12-14 mm, minimum inhibitory concentration (MIC) 32 mug/ml; penicillin disk diameter 6 mm, MIC 32 mug/ml and sensitive by both methods to spectinomycin, cefuroxime, ceftriaxone and ciprofloxacin. All isolates were of the same serogroup (WI). Ten of the strains, including the 9 from Tandil outbreak, were arginine-requiring, while the other 2 were methionine and arginine-requiring. All of them demonstrate the same plasmid profile (2.6, 3.2, 25.2 MDa). They were positive for the tetM determinant and the restriction analysis identified it as a Dutch-type plasmid. In spite of the temporal and geographical dispersion, PP-TRNG strains in Argentina seem to be highly homogeneous in terms of antimicrobial susceptibility, serogroup, plasmid profiles and even auxotype.
ACCESSION #
22202352

 

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