TITLE

Human pancreatitis and the role of cathepsin B

AUTHOR(S)
Lerch, M. M.; Halangk, W.
PUB. DATE
September 2006
SOURCE
Gut;Sep2006, Vol. 55 Issue 9, p1228
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the significance of cathepsin B polymorphisms in pancreatitis. Cathepsin B activates trypsinogen. Research revealed that 90 percent of intrapancreatic activation of trypsinogen during pancreatitis is dependent on the presence of cathepsin B. It has been discovered that L26V mutation affects the capacity of cathepsin B to activate mesotrypsin, which can inhibit cationic trypsin. This cationic trypsin has a significant role in pancreatitis.
ACCESSION #
22184101

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics