Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies?

Pizarro, T. T.; de la Rue, S. A.; Cominelli, F.
September 2006
Gut;Sep2006, Vol. 55 Issue 9, p1226
Academic Journal
The article focuses on the significance of interleukin 6 (IL-6) in Crohn's ileitis in the murine model SAMP/Yit. Research revealed that administration of hyper IL-6 increased the severity of the disease in the mice. On the other hand, treatment with an inhibitor of IL-6 improves the severity of the disease. It has been discovered that IL-6 blockade has the ability to suppress the disease in the mice.


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