TITLE

SHV-5 EXTENDED-SPECTRUM β-LACTAMASES IN CLINICAL ISOLATES OF ESCHERICHIA COLI IN MALAYSIA

AUTHOR(S)
Subramaniam, G.; Palasubramaniam, S.; Navaratnam, P.
PUB. DATE
July 2006
SOURCE
Indian Journal of Medical Microbiology;Jul2006, Vol. 24 Issue 3, p205
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Escherichia coli isolates resistant to ceftazidime isolated in the University Malaya Medical Center (UMMC) Kuala Lumpur, Malaysia, between the years 1998 and 2000 were studied for extended-spectrum β-lactamase (ESBL) production. All strains were analysed phenotypically and genotypically and found to be ESBL-producing organisms harbouring SHV5 β-lactamase. This was confirmed by PCR-SSCP and nucleotide sequencing of the blaSHV amplified gene. As there was no evidence of ESBL activity in E. coli prior to this, coupled with the fact that there was a predominance of SHV-5 β-lactamases in Klebsiella pneumoniae isolates in UMMC, we postulate that the E. coli obtained the SHV-5 β-lactamase genes by plasmid transfer from the ESBL-producing K. pneumoniae.
ACCESSION #
22150600

 

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