STOCHASTIC THRESHOLDS: A NOVEL EXPLANATION OF NONLINEAR DOSE-RESPONSE RELATIONSHIPS FOR STOCHASTIC RADIOBIOLOGICAL EFFECTS
- LOW-LET-INDUCED RADIOPROTECTIVE MECHANISMS WITHIN A STOCHASTIC TWO-STAGE CANCER MODEL. Sch�llnberger, H.; Stewart, R. D.; Mitchel, R. E. J. // Dose-Response;2005, Vol. 3 Issue 4, p508
A stochastic two-stage cancer model with clonal expansion was used to investigate the potential impact on human lung cancer incidence of some aspects of the hormesis mechanisms suggested by Feinendegen (Health Phys. 52 663--669, 1987). The model was applied to low doses of low-LET radiation...
- Dose-Rate Effect on Proliferation Suppression in Human Cell Lines Continuously Exposed to ?? Rays. Magae, Junji; Furukawa, Chiharu; Ogata, Hiromitsu // Radiation Research;Oct2011, Vol. 176 Issue 4, p447
Irradiation time and dose rate are important factors in the evaluation of radiation risk for human health. We previously proposed a novel dose-rate effect model, the modified exponential (MOE) model, which predicts that radiation risks decline exponentially as the dose rate decreases. Here we...
- Targeted Radiotherapy: Microgray Doses and the Bystander Effect. Mairs, Robert J.; Fullerton, Natasha E.; Zalutsky, Michael R.; Boyd, Marie // Dose-Response;2007, Vol. 5 Issue 3, p204
Indirect effects may contribute to the efficacy of radiotherapy by sterilizing malignant cells that are not directly irradiated. However, little is known of the influence of indirect effects in targeted radionuclide treatment. We compared ?-radiation-induced bystander effects with those...
- Protective Bystander Effects Simulated with the State-Vector Model. Sch�llnberger, Helmut; Eckl, Peter M. // Dose-Response;2007, Vol. 5 Issue 3, p187
Apoptosis induced in non-hit bystander cells is an important biological mechanism which operates after exposure to low doses of low-LET radiation. This process was implemented into a deterministic multistage model for in vitro neoplastic transformation: the State-Vector Model (SVM). The new...
- Effect of Dose Rate of Irradiation on Ultrastructure of Duodenal Mucosa. Labéjof, L.; Mororó, I.; Galle, P.; Barbosa, G.; Severo, M. I.; de Oliveira, A. H. // World Academy of Science, Engineering & Technology;Aug2010, Issue 44, p664
No abstract available.
- Comparison of the dose—response relationship of radiation-induced apoptosis in the hippocampal dentate gyrus and intestinal crypt of adult mice. Kim, J. S.; Yang, M.; Kim, J.; Lee, D.; Kim, J. C.; Shin, T.; Kim, S. H.; Moon, C. // Radiation Protection Dosimetry;Mar2012, Vol. 148 Issue 4, p492
The present study compared the doseâ€“response curves for the frequency of apoptosis in mouse hippocampal dentate gyrus (DG) and intestinal crypt using whole-body gamma irradiation. The incidence of gamma-ray-induced apoptosis was measured using the terminal deoxynucleotidyl...
- Preface. Sykes, Pamela; Mitchel, Ron; Higson, Donald // Dose-Response;2007, Vol. 5 Issue 4, p256
A preface for the October 2007 issue of the "Dose-Response" is presented.
- STATISTICAL CHALLENGES IN EVALUATING DOSE-RESPONSE USING EPIDEMIOLOGICAL DATA. Mundt, Kenneth A. // Dose-Response;2005, Vol. 3 Issue 4, p453
The article discusses various reports published within the issue, including one by Kenny S. Crump on the impact of random error on the assessment of the shape of the dose-response and another by Edwin van Wijngaarden on graphical approach for uncovering dose-responses.
- Lose-Dose Abdominal CT for Appendicitis. Kuritzky, Louis // Internal Medicine Alert;6/15/2012 Supplement, p87
The article informs that the use of low-dose abdominal computed tomography (AB-CT) scan to diagnose appendicitis is as effective as high-dose AB-CT.