Survival after resection for primary lung cancer: a population based study of 3211 resected patients

Strand, T.-E.; Rostad, H.; Møller, B.; Norstein, J.
August 2006
Thorax;Aug2006, Vol. 61 Issue 8, p710
Academic Journal
Background: Very few population based results have been presented far survival after resection far lung cancer. The purpose of this study was to present long term survival after resection and to quantify prognostic factors far survival. Methods: All lung cancer patients diagnosed in Norway in 1993-2002 were reported to the Cancer Registry of Norway (n = 19 582). A total of 3211 patients underwent surgical resection and were included far analysis. Supplementary information from hospitals (including co-morbidity data) was collected far patients diagnosed in 1993-8. Five year observed and relative survival was analysed far patients diagnosed and operated in 1993-9. Factors believed to influence survival were analysed by a Cox proportional hazard regression model. Results: Five year relative survival in the period 1993-9 was 46.4% (n = 2144): 58.4% far stage I disease (n = 1375), 28.4% far stage II (n = 532), 15.1% far IIIa (n = 133), 24.1% far IIIb (n = 63), and 21.1% far stage IV disease (n=41). The high survival in stage IIIb and IV was due to the contribution of multiple tumours. Cox regression analysis identified male sex, higher age, procedures other than upper and middle lobectomy, histologies such as adenocarcinoma and large cell carcinoma, surgery on the right side, infiltration of resection margins, and larger turnout size as non-favourable prognostic factors. Conclusions: Survival was favourable for resected patients in a population based group including subgroups such as elderly patients, those with advanced stage, small cell lung cancer, tumours with nodal invasion, and patients with multiple tumours. These results question the validity of the current TNM system far lung cancer with regard to tumour size and categorization of multiple tumours.


Related Articles

  • Is lobectomy really more effective than sublobar resection in the surgical treatment of second primary lung cancer?†. Zuin, Andrea; Andriolo, Luigi Gaetano; Marulli, Giuseppe; Schiavon, Marco; Nicotra, Samuele; Calabrese, Francesca; Romanello, Paola; Rea, Federico // European Journal of Cardio-Thoracic Surgery;Aug2013, Vol. 44 Issue 2, pe120 

    OBJECTIVES Sublobar resection for early-stage lung cancer is still a controversial issue. We sought to compare sublobar resection (segmentectomy or wedge resection) with lobectomy in the treatment of patients with a second primary lung cancer. METHODS From January 1995 to December 2010, 121...

  • Management and Surgical Resection for Tumors of the Trachea and Carina: Experience with 32 Patients. Liu, Xiang-Yan; Liu, Fan-Ying; Wang, Zhou; Chen, Gang // World Journal of Surgery;Dec2009, Vol. 33 Issue 12, p2593 

    Background: The purpose of the present study was to investigate the complications, long-term survival, and management lessons learned after surgical resection for patients with primary tumors of the trachea and carina and locally advanced lung cancer directly infiltrating the carina. Methods: A...

  • Operating on a suspicious lung mass without a preoperative tissue diagnosis: pros and cons†. Sihoe, Alan D.L.; Hiranandani, Raj; Wong, Henry; Yeung, Enoch S.L. // European Journal of Cardio-Thoracic Surgery;Aug2013, Vol. 44 Issue 2, p231 

    OBJECTIVES Patients with a suspicious lung mass sometimes receive surgery with no preoperative tissue diagnosis despite—and sometimes in lieu of—modern medical investigations. The pros and cons of doing so have rarely been studied. METHODS Pulmonary surgery was performed in 443...

  • Comparison of surgical results after pneumonectomy and sleeve lobectomy for non-small cell lung cancer.: Trends over time and 20-year institutional experience. Takeda, Shin-ichi; Maeda, Hajime; Koma, Masaru; Matsubara, Yoko; Sawabata, Noriyoshi; Inoue, Masayoshi; Tokunaga, Toshiteru; Ohta, Mitsunori // European Journal of Cardio-Thoracic Surgery;Mar2006, Vol. 29 Issue 3, p276 

    Abstract: Objective: Sleeve lobectomy is a lung-saving procedure for central tumors for which the alternative is pneumonectomy. The purpose of this study was to report the clinical characteristics, operative results, survival, and late outcomes over 20 years in patients who underwent sleeve...

  • Limited resection and two-staged lobectomy for non-small cell lung cancer with ground-glass opacity. Ohtaka, Kazuto; Hida, Yasuhiro; Kaga, Kichizo; Kato, Tatsuya; Muto, Jun; Nakada-Kubota, Reiko; Hirano, Satoshi; Matsui, Yoshiro // Journal of Cardiothoracic Surgery;2013, Vol. 8 Issue 1, p1 

    Background: Lung tumors showing ground-glass opacities on high-resolution computed tomography indicate the presence of inflammation, atypical adenomatous hyperplasia, or localized bronchioloalveolar carcinoma. We adopted a two-staged video-assisted thoracoscopic lobectomy strategy involving...

  • Research for Mediastinal Lymph Node Disection Style of Stage Ib Upper Lobe Non-small Cell Lung Cancer. Wenli WANG; Feng MAO; Yang SHEN-TU; Yunqing MEI // Chinese Journal of Lung Cancer;Nov2013, Vol. 16 Issue 11, p584 

    Background and objective Lymphatic metastasis is the most important way for the spread of lung cancer and is one of the important factors affecting the prognosis. Existing studies showed that compared to middle or lower lobe NSCLC, upper lobe non-small cell lung cancer (NSCLC) has a higher...

  • Intrapulmonary Solitary Fibrous Tumour of the Lung: A Very Unusual Presentation. Yaran, Pınar; Taştepe, Abdullah İrfan; Yazıcı, Ülkü; Sak, Serpil Dizbay // Balkan Medical Journal;Dec2011, Vol. 28 Issue 4, p466 

    Solitary fibrous tumour (SFT) is a rare neoplasm which most frequently occurs in the pleura, especially visceral pleura, but it is known that intrapulmonary SFT is very rare. We report the case of a 60-year-old woman who was admitted with a 6-year history of slow enhancing intrapulmonary nodular...

  • Can non-performance of radical systematic mediastinal lymphadenectomy be justified in elderly lung cancer patients? An evaluation using propensity-based survival analysis. Okasaka, Toshiki; Usami, Noriyasu; Taniguchi, Tetsuo; Kawaguchi, Koji; Okagawa, Takehiko; Suzuki, Haruko; Matsuo, Keitaro; Yokoi, Kohei // European Journal of Cardio-Thoracic Surgery;Jul2010, Vol. 38 Issue 1, p27 

    Abstract: Objectives: The increasing age of the population has raised the importance of determining the minimally required surgical treatment for elderly lung cancer patients. Despite a number of previous studies, the therapeutic impact of a radical mediastinal lymphadenectomy (RLA) associated...

  • Stereotactic Body Radiation Therapy: Approaches in Early-Stage NSCLC. Nichols, Emma Hitt // MD Conference Express;Jun2014, Vol. 14 Issue 3, p17 

    Stereotactic body radiation therapy (SBRT) is effective in patients with early-stage non—small cell lung cancer (NSCLC) who are either medically inoperable or high-risk operable. This article discusses treatment approaches and considerations for the use of SBRT in this population.


Read the Article


Sign out of this library

Other Topics