TITLE

Differences in motor activation of voluntary and reflex cough in humans

AUTHOR(S)
Lasserson, D.; Mills, K.; Arunachalam, R.; Polkey, M.; Moxham, J.; Kalra, L.
PUB. DATE
August 2006
SOURCE
Thorax;Aug2006, Vol. 61 Issue 8, p699
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To study motor activation patterns of voluntary and reflex cough adjusted for cough flow rotes. Methods: Surface electromyography (EMG) and cough flow rate were measured in 10 healthy volunteers. Voluntary cough was assessed for 20 efforts in each quintile of increasing cough flow rate. Reflex cough was assessed for 25 efforts produced by nebulised L-tartaric acid. EMG was recorded over the expiratory (rectus abdominis, obliques, lower intercostals) and accessory (trapezius, pectoralis major, deltoid, latissimus dorsi) muscles. EMG activity, burst duration and onset were compared for each quintile of voluntary cough, and between voluntary and reflex cough matched for cough flow rate. Results: EMG activity and burst duration of expiratory and accessory muscles during voluntary cough increased in proportion to cough flow. Expiratory muscles had longer EMG burst duration (difference 68 ms (95% CI 34 to 102), p<0.01) and earlier onset of EMG activity (difference 44 ms (95% CI 20 to 68), p<0.0001) compared with accessory muscles. EMG activity in all muscles was increased (mean 110.2% v 56.1%, p<0.001) and burst duration (mean 206 ms v 280 ms, p = 0.013) decreased in reflex cough compared with voluntary cough of equal flow rate. There were no differences in EMG onset (difference 8 ms (95% CI 25 to 9) or burst duration (difference 27 ms (95% CI 58 to -4) between expiratory and accessory muscles. Conclusions: Functional organisation of motor activity differs between voluntary and reflex cough. Voluntary cough is characterised by sequential activation whereas reflex cough is associated with early and simultaneous activation of expiratory and accessory muscles.
ACCESSION #
22074182

 

Related Articles

  • Capsaicin cough sensitivily in bronchiectasis. Torrego, A.; Haque, R. A.; Nguyen, L. T.; Hew, M.; Carr, D. H.; Wilson, R.; Chung, K. F. // Thorax;Aug2006, Vol. 61 Issue 8, p706 

    Background: Bronchiectosis is a suppurative airway disease charocterised by persistent cough and sputum production associated with bronchial dilatation. A study was undertaken to determine whether cough sensitivity is increased in bronchiectatic patients. Methods: Twenty two patients with...

  • Review: Inhaled corticosteroids slow the progression of airflow limitation in COPD.  // ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p57 

    In patients with chronic obstructive pulmonary disease (COPD), inhaled corticosteroids reduce the progression of airflow limitation. Inhaled corticosteroids (ICS) slow the progression of airflow limitation in COPD Studies were selected if they were full reports of randomized controlled trials of...

  • Poor reporting may infer poor science: lessons learned from asthma trials. Been, Jasper V.; Kotz, Daniel; van Schayck, Onno C. P. // Primary Care Respiratory Journal;Dec2013, Vol. 22 Issue 4, p388 

    The article presents the author's views on asthma trials. The author states that there is considerable room for improvement in clinical trial reporting quality. It is also stated that although randomised controlled trial (RCT) is the gold standard for research, methodology or trial processes...

  • mecysteine hydrochloride.  // Royal Society of Medicine: Medicines;2002, p348 

    This article presents information on mecysteine hydrochloride or methyl cysteine hydrochloride, a drug used to reduce the viscosity of sputum and so acts as an expectorants in patients with disorders of the upper respiratory tract (eg chronic asthma or bronchitis). Administration is oral.

  • Open Clinical Trial Shows Potential for Butterbur Root Extract in Asthma Treatment. Oliff, Heather S.; Blumenthal, Mark // HerbalGram;Fall2005, Issue 68, p28 

    This article reports on a study which found that butterbur root extract is beneficial in asthma treatment. Butterbur root powder has been shown to improve lung function in patients with chronic asthma and chronic bronchitis. The active compounds are thought to be petasins, a group of...

  • Assessing the potential for outcome reporting bias in a review: a tutorial. Dwan, Kerry; Gamble, Carrol; Kolamunnage-Dona, Ruwanthi; Mohammed, Shabana; Powell, Colin; Williamson, Paula R. // Trials;2010, Vol. 11, p52 

    Background: Outcome reporting bias (ORB) occurs when variables are selected for publication based on their results. This can impact upon the results of a meta-analysis, biasing the pooled treatment effect estimate. The aim of this paper is to show how to assess a systematic review and...

  • Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people. Sinha, Ian P; Gallagher, Ruairi; Williamson, Paula R; Smyth, Rosalind L // Trials;2012, Vol. 13 Issue 1, p103 

    Abstract: Background: In clinical trials in childhood asthma, outcomes reflecting short-term disease activity are frequently measured, whilst functional status, quality of life (QoL), and long-term treatment effects are rarely assessed. There is also non-uniformity across studies in the...

  • Targeted routine asthma care in general practice using telephone triage. Gruffydd-Jones, Kevin; Hollinghurst, Sandra; Ward, Sabbi; Taylor, Gordon // British Journal of General Practice;Dec2005, Vol. 55 Issue 521, p918 

    Background There is a high non-attendance rate for traditional clinic-based routine asthma care in general practice. Alternative methods of providing routine asthma care need to be examined. Aim To examine the cost and effectiveness of targeted routine asthma care in general practice using...

  • Asthma action plans. Jarvis, Sarah // Practice Nurse;2/10/2006, Vol. 31 Issue 3, p33 

    The article presents information on asthma action plans. The term asthma action plan was substituted for the older term self management plan because of patient preference. Several randomised controlled trials have found that individualised written asthma action plans are effective for both...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics