TITLE

Long term effects of antenatal betamethasone on lung function: 30 year follow up of a randomised controlled trial

AUTHOR(S)
Dalziel, S. R.; Rea, H. H.; Walker, N. K.; Parag, V.; Mantell, C.; Rodgers, A.; Harding, J. E.
PUB. DATE
August 2006
SOURCE
Thorax;Aug2006, Vol. 61 Issue 8, p678
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Antenatal betamethasone is routinely used for the prevention of neonatal respiratory distress syndrome in preterm infants. However, little is known of the long term effects of exposure to antenatal betamethasone on lung function in adulthood. Methods: Five hundred and thirty four 30 year olds whose mothers had participated in the first and largest randomised controlled trial of antenatal betamethasone were followed. Lung function was assessed by portable spirometric testing. The prevalence of asthma symptoms was assessed using the European Community Respiratory Health Survey questionnaire. Results: Fifty (20%) betamethasone exposed and 53 (19%) placebo exposed participants met the criteria for current asthma (relative risk 0.98 (95% CI 0.74 to 1.30), p=0.89). 181 betamethasone exposed and 202 placebo exposed participants had acceptable spirometric data. There were no differences in lung function between betamethasone and placebo exposed groups (mean (SD) Forced vital capacity in the betamethasone and placebo groups 105.9 (12.0) v 106.6 (12.6)% predicted, difference = -0.7 (95% CI -3.2 to 1.8), p=0.59; mean (SD) forced expiratory volume in 1 second in the betamethasone and placebo groups 98.9 (13.4) v 98.5 (13.6)% predicted, difference=0.3 (95% CI -2.4 to 3.1, p = 0.80)). Conclusions: Antenatal exposure to a single course of betamethasone does not alter lung function or the prevalence of wheeze and asthma at age 30.
ACCESSION #
22074175

 

Related Articles

  • "Causes of death in asthma, COPD and non-respiratory hospitalized patients: a multicentric study". Soto-Campos, Jose Gregorio; Plaza, Vicente; Soriano, Joan B.; Cabrera-López, Carlos; Almonacid-Sánchez, Carlos; Vazquez-Oliva, Rosa M.; Serrano, Jose; Ballaz-Quincoces, Aitor; Padilla-Galo, Alicia; Santos, Vanessa // BMC Pulmonary Medicine;2013, Vol. 13 Issue 1, p1 

    Background There is limited information on the causes of death in asthma patients. To determine the causes of death in hospitalized asthmatic patients and to compare with those observed in COPD patients and non-respiratory individuals, with a particular interest in associations with previous...

  • Review: daily salmeterol increases non-fatal serious adverse events in chronic asthma. Cates, C. J. // Evidence Based Medicine;Feb2009, Vol. 14 Issue 1, p6 

    The article presents a review on the daily salmeterol increases non-fatal serious adverse events in chronic asthma. The review analyzes the effect of the daily salmeterol in the chronic asthma patients. Studies compared salmeterol with placebo or short-acting ß-antagonists in patients with...

  • Mild persistent asthma and inhaled corticosteroids: is daily therapy really necessary? Bauchner, Howard // Archives of Disease in Childhood;Oct2005, Vol. 90 Issue 10, p1094 

    This article cites a study on the treatment of mild persistent asthma, which was published in the May 6, 2005 issue of the "Journal Watch Pediatrics and Adolescent Medicine." In this double-blind trial, researchers randomized 225 adults with mild persistent asthma to receive twice-daily inhaled...

  • Analysis. Summerton, Nick // Update;5/19/2005, Vol. 70 Issue 5, p26 

    This article presents a study to find out whether intermittent as-needed corticosteroid treatment for mild persistent asthma equivalent to regular daily treatment. Treatment with daily or intermittent corticosteroid therapy in a six-centre randomised controlled trial was conducted. After...

  • Pairwise Comparison of Levalbuterol versus Racemic Albuterol in the Treatment of Moderate-to-Severe Asthma. Pleskow, Warren W.; Nelson, Harold S.; Schaefer, Kendyl; Claus, Raymond; Roach, James M. // Allergy & Asthma Proceedings;Nov/Dec2004, Vol. 25 Issue 6, p429 

    The object of this study is a post hoc pairwise comparison of levalbuterol versus racemic albuterol for asthma in a multicenter, double-blind, randomized, placebo-controlled clinical trial. The participants are patients ⩾12 years of age (n = 362) with FEV1 45-70% of predicted. The patients...

  • Salbutamol.  // Reactions Weekly;9/29/2007, Issue 1171, p24 

    The article presents a case study of a 41-year-old man, who had a 40 pack/year smoking history and a 3-year history of asthma, experienced bronchoconstriction following inhalation of salbutamol for asthma exacerbation. After receiving methylprednisolone and formoterol, he felt breathless and...

  • Editor's Choice.  // Respiratory Care;Oct2008, Vol. 53 Issue 10, p1258 

    The article presents abstracts on medical topics which include the prognostic value of plasma n-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome, several exacerbations in children with mild asthma, and lung stress and strain during mechanical ventilation...

  • How to Move From Belief to Proof? Articulating the Value of Chronic Disease and Care Management Programs for Adults With Asthma. Steuten, Lotte M. G. // Respiratory Care;Jul2009, Vol. 54 Issue 7, p844 

    The article reflects on the significance and limitations of the study about the value of chronic disease and care management programs for adults suffering from asthma conducted by Matthew L. Maciejewski. The author indicates that Maciejewski sees that more randomized controlled trials need to be...

  • Detailed postal feedback about prescribing to asthma patients combined with a guideline statement showed no impact: a randomised controlled trial. Søndergaard, Jens; Andersen, Morten; Vach, Kirstin; Kragstrup, Jakob; Maclure, Malcolm; Gram, Lars F. // European Journal of Clinical Pharmacology;May2002, Vol. 58 Issue 2, p127 

    Objective. To evaluate the effects of postal feedback with clinically relevant data on general practitioners' prescribing compared with feedback with aggregate data on prescribing patterns of asthma drugs. Methods. The study was a randomised, controlled trial. The general practitioners (GPs) in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics