The Absence of Anti-Tat Antibodies Is Associated with Risk of Disease Progression in HIV-2 Infection

Rodriguez, Shaun K.; Dieng Sarr, Abdoulaye; Olorunnipa, Olushola; Popper, Stephen J.; Gueye-Ndiaye, Aissatou; Traoré, Ibrahima; Dia, Mamadou C.; Mboup, Souleymane; Kanki, Phyllis J.
September 2006
Journal of Infectious Diseases;9/15/2006, Vol. 194 Issue 6, p760
Academic Journal
The Tat protein of human immunodeficiency virus (HIV) is essential for viral replication and has extracellular pathogenic activity. We sought to determine whether the anti-Tat antibody response was predictive of disease progression in 144 HIV type 2 (HIV-2)-infected subjects observed longitudinally between 1985 and 2003. Sixty-eight percent of the subjects tested positive for anti-Tat antibodies, with reactivity notably established early after seroconversion and stably maintained over the course of infection. The risk and rate of progression to advanced HIV-2 AIDS was significantly higher in anti-Tat-negative subjects than in anti-Tat-positive subjects, extending the importance of this prognostic marker for HIV-2 AIDS.


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