TITLE

The Mtb proteasome: an open and shut case

AUTHOR(S)
Amoils, Shannon
PUB. DATE
May 2006
SOURCE
Nature Reviews Microbiology;May2006, Vol. 4 Issue 5, p325
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports about the detailed biochemistry and structure of the Mycobacterium tuberculosis (Mtb) 20S proteasome, a new member of the prokaryotic proteasomes which are rare breeds. A study solved the crystal structure of the Mtb proteasome at 3.0-Ã… resolution and revealed that its overall architecture is similar to that of archaeal and eukaryotic proteasomal systems. Findings show that Mtb play crucial role in mycobacterial defense to host nitrosative stress.
ACCESSION #
22005540

 

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