The Early History of Giant Cell Arteritis and Polymyalgia Rheumatica: First Descriptions to 1970

Hunder, Gene G.
August 2006
Mayo Clinic Proceedings;Aug2006, Vol. 81 Issue 8, p1071
Academic Journal
Giant cell arteritis and polymyalgia rheumatica were described separately more than 100 years ago. However, the original reports of both conditions were neglected for many years. After the article by Horton et al on giant cell arteritis In the 1930s and studies published by others in the 1940s, giant cell arteritis began to be recognized as a specific disease. In the 1950s and 1960s, many of the numerous presentations and complications of giant cell arteritis were recorded. In a somewhat similar fashion, physicians became cognizant of polymyalgia rheumatica only after several Independent descriptions In the 1940s and 1950s. The rapid response of both syndromes to glucocorticoid therapy was discovered shortly after cortisone's effect on rheumatoid arthritis was described. The origin of the proximal aching and stiffness in polymyalgia rheumatica was more difficult to understand. The relatively minor findings In the Joints on physical examination seemed Insufficient to account for the severe discomfort. As the link between polymyalgia rheumatica and giant cell arteritis be- came apparent, some thought the aching In polymyalgia rheumatica was related to vasculitis. The debate about whether proximal synovitis or vasculitis was the cause of the symptoms continued after 1970. Although the reason these 2 conditions were associated was not considered by 1970, the establishment of the syndromes as clinically linked entitles provided the groundwork for further progress In the next decades.


Related Articles

  • Revmatická polymyalgie -- je účinná biologická léčba? A., Pavelková // Czech Rheumatology / Ceska Revmatologie;2013, Vol. 21 Issue 4, p183 

    Both polymyalgia rheumatica (PMR) and giant-cell arteritis (temporal arteritis, TA) relatively often affect people in old age, have an acute course and cause significant functional impairment. Manifestations of PMR can often resemble those of rheumatoid arthritis (RA). Thus, to differentiate...

  • A 24-Year-Old Man with Symptoms and Signs of Polymyalgia Rheumatica. Whittaker, Paul E.; Fitzsimons, Michael G. // Journal of Family Practice;Jul1998, Vol. 47 Issue 1, p68 

    Most physicians regard polymyalgia rheumatica (PMR) as a disease that affects only the elderly. This case report of a 24-year-old man with proximal limb girdle muscle pain, stiffness, tenderness, weakness, and an elevated erythrocyte sedimentation rate, who had a dramatic response to steroids,...

  • Diagnosis and management of giant cell arteritis and polymyalgia rheumatica: challenges, controversies and practical tips. Mackie, Sarah Louise; Pease, Colin Thomas // Postgraduate Medical Journal;May2013, Vol. 89 Issue 1051, p284 

    Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory rheumatic diseases that may present to a variety of disciplines and specialities. The mainstay of treatment is glucocorticoids (steroids); together PMR and GCA now represent one of the most common reasons for...

  • Polymyalgia rheumatica and colon malignacy: case report. Kehler, Tatjana; Ćurković, Božidar // Clinical Rheumatology;Oct2006, Vol. 25 Issue 5, p764 

    Polymyalgia rheumatica (PMR) is a relatively common disorder in the elderly. Whereas the relationship between polymyalgia rheumatica and giant cell arteritis (GCA) is well recognized, there is still controversy about PMR and malignancy. We are presenting a patient with PMR and adenocarcinoma of...

  • Level of Adherence to Prophylactic Osteoporosis Medication amongst Patients with Polymyalgia Rheumatica and Giant Cell Arteritis: A Cross-Sectional Study. Emamifar, A.; Gildberg-Mortensen, Rannveig; Andreas Just, S.; Lomborg, N.; Asmussen Andreasen, R.; Jensen Hansen, I. M. // International Journal of Rheumatology;9/29/2015, Vol. 2015, p1 

    Objective. To estimate level of adherence to oral calcium and vitamin D supplementation as well as bisphosphonate amongst patients with PMR and GCA treated with glucocorticoids. Method. A total of 138 patients with the diagnosis of PMR and/or GCA registered in our department in December 2013. In...

  • Síndrome hemofagocítico en paciente con polimialgia reumática. García, Roberto Hurtado; Villena, Paola Beneit; Guillén, Sonia Martín; Bernabéu, Alicia Pérez // Reumatologia Clinica;ene/feb2016, Vol. 12 Issue 1, p50 

    No abstract available.

  • Polymyalgia rheumatica and giant cell arteritis. Pountain, Gillian; Hazleman, Brian // BMJ: British Medical Journal (International Edition);4/22/95, Vol. 310 Issue 6986, p1057 

    Reports on polymyalgia rheumatica and giant cell arteritis. Aetiology; Investigations; Treatment; Diagnosing relapse of polymyalgia rheumatica and giant cell arteritis.

  • Polymyalgia rheumatica and temporal arteritis: Diagnosis and management. Swannell, A.J. // BMJ: British Medical Journal (International Edition);05/03/97, Vol. 314 Issue 7090, p1329 

    Presents information on diagnosis and management of polymyalgia rheumatica and temporal arteritis. Clinical presentation; Ophthalmic features of giant cell arteritis; Diagnostic investigation; Differential diagnosis.

  • Giant cell arteritis and polymyalgia rheumatica. Kagen, Lawrence J. // Cortlandt Forum;01/25/98, Vol. 11 Issue 1, p179 

    Deals with giant cell arteritis and polymyalgia rheumatica. Typical symptoms of giant cell arteritis; Laboratory tests that are helpful in diagnosis; Arteries commonly affected; Laboratory findings to indicate polymyalgia rheumatica; Disorders to be considered in differential diagnosis;...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics