TITLE

Effect of Antiviral Chemoprophylaxis on Adverse Clinical Outcomes Associated With Cytomegalovirus After Liver Transplantation

AUTHOR(S)
Walter C. Hellinger; Hugo Bonatti; Victor I. Machicao; Joseph D. Yao; Lisa M. Brumble; Salvador Alvarez; Stephen D. Weigand; Rolland C. Dickson; Denise M. Harnois; James R. Spivey; Wolf H. Stapelfeldt; Christopher B. Hughes; Justin H. Nguyen; Jeffery L. Steers
PUB. DATE
August 2006
SOURCE
Mayo Clinic Proceedings;Aug2006, Vol. 81 Issue 8, p1029
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To assess the association between cytomegalovirus (CMV) serology of donor and recipient and adverse outcomes after liver transplantation in the era of effective antiviral chemoprophylaxis. PATIENTS AND METHODS: We performed a retrospective cohort study of 193 consecutive patients undergoing their first liver transplantation between February 1998 and July 2000 with targeted and preemptive ganciclovir chemoprophylaxis. Patients were divided into 4 groups by CMV serology of donor and recipient: donor-/recipient-; donor-/recipient+; donor+/recipient+; and donor+/recipient-. Survival to the end points of retransplantation, death, or survival to 1 year after transplantation (whichever occurred first) was assessed. Rates of bacterial, fungal, and CMV Infection and of CMV disease were recorded and compared. RESULTS: No significant differences were observed in the rates of retransplantation, death, or survival to 1 year among the 4 groups of patients. Despite significantly higher rates of CMV Infection in the donor+ groups, there were no differences in the rates of bacterial or fungal infection or of CMV disease. Rejection occurred least frequently In the donor-/recipient-group. CONCLUSION: The adverse effects of CMV on outcomes after liver transplantation have been diminished in the era of effective antiviral chemoprophylaxis.
ACCESSION #
21973043

 

Related Articles

  • Dynamics of Cytomegalovirus Replication during Preemptive Therapy with Oral Ganciclovir. Razonable, Raymund R.; van Cruijsen, Hester; Brown, Robert A.; Wilson, Jennie A.; Harmsen, William S.; Wiesner, Russell H.; Smith, Thomas F.; Paya, Carlos V. // Journal of Infectious Diseases;6/1/2003, Vol. 187 Issue 11, p1801 

    The degree and dynamics of cytomegalovirus (CMV) replication were investigated in blood samples that were prospectively collected in the context of a placebo-controlled study evaluating the efficacy of preemptive oral ganciclovir for the prevention of CMV disease after liver transplantation. The...

  • High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver Transplant Recipients. Singh, Nina; Yu, Victor L.; Mieles, Luis; Wagener, Marilyn M.; Miner, Richard C.; Gayowski, Timothy // Annals of Internal Medicine;3/1/94, Vol. 120 Issue 5, p375 

    Examines the efficacy of high-dose oral acyclovir therapy compared with preemptive, short-course ganciclovir therapy to prevent cytomegalovirus (CMV) disease in liver transplant recipients. Definition of preemptive therapy; Effects of CMV on humans; Impact of high-dose oral acyclovir on the...

  • ViroPharma Starts Phase III Trial Of Camvia In Liver Transplants. Shrine, Jim // BioWorld Today;7/6/2007, Vol. 18 Issue 130, p1 

    The article reports on a second Phase III trial conducted by ViroPharma Inc. for its anti-cytomegalovirus (CMV) agent maribavir. The trial is aimed at preventing infection in patients undergoing liver transplantation. ViroPharma's Camvia will be tested against oral ganciclovir in the prevention...

  • Delayed Occurrence of Cytomegalovirus Disease in Organ Transplant Recipients Receiving Antiviral Prophylaxis: Are We Winning the Battle Only to Lose the War? Singh, N. // European Journal of Clinical Microbiology & Infectious Diseases;Sep2002, Vol. 21 Issue 9, p643 

    The article presents information on delayed occurrence of cytomegalovirus (CMV) disease in organ transplant recipients receiving antiviral prophylaxis. CMV has long been recognized as a significant opportunistic pathogen in organ transplant recipients. The early 1990s marked the beginning of a...

  • Oral Valganciclovir as a Preemptive Treatment for Cytomegalovirus (CMV) Infection in CMV-Seropositive Liver Transplant Recipients. Kim, Jong Man; Kwon, Choon Hyuck David; Joh, Jae-Won; Ha, Young Eun; Sinn, Dong Hyun; Choi, Gyu-Seong; Peck, Kyong Ran; Lee, Suk-Koo // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    Objectives: Cytomegalovirus (CMV) infections in liver transplant recipients are common and result in significant morbidity and mortality. Intravenous ganciclovir or oral valganciclovir are the standard treatment for CMV infection. The present study investigates the efficacy of oral...

  • Effect of cytomegalovirus infection status on first-year mortality rates among orthotopic liver... Falagas, Matthew E.; Snydman, David R. // Annals of Internal Medicine;02/15/97, Vol. 126 Issue 4, p275 

    Presents the results of a study investigating the effect of cytomegalovirus (CMV) infection on 1-year mortality rates in orthotopic liver transplant recipients. CMV infection as a risk factor for liver transplant mortality; Significance of donor and recipient CMV serologic status as a...

  • Drug Works For Resistant CMV. SCHIESZER, JOHN // Renal & Urology News;Oct2013, Vol. 12 Issue 10, p1 

    The article reports on the study conducted by infectious diseases clinical specialist Katherine Perez and colleagues which shows the possible usefulness of cidofovir antiviral agent in treating ganciclovir-resistant cytomegalovirus (CMV) infections in solid organ transplant (SOT) recipients.

  • 9-(1,3-dihydroxy-2-propoxymethyl)guanine for Cytomegalovirus Infections in Patients with the Acquired Immunodeficiency Syndrome. Bach, Michael C.; Bagwell, Sandra P.; Knapp, Nancy P.; Davis, Kent M.; Hedstrom, Peter S. // Annals of Internal Medicine;Sep85, Vol. 103 Issue 3, p381 

    Describes the use of 9-(1,3-dihydroxy-2-propoxymethyl) guanine, a nucleoside antiviral agent for cytomegalovirus infections in AIDS patients. Case reports on the patients; Efficacy of the agent against cytomegalovirus.

  • Economic Evaluation of Systemic Treatments for Cytomegalovirus Retinitis in Patients with AIDS. Lee, T.A.; Sullivan, S.D.; Veenstra, D.L.; Ramsey, S.D.; Steger, P.J.K.; Malinverni, R.; Pleil, A.M.; Williamson, T. // PharmacoEconomics;May2001, Vol. 19 Issue 5, p535 

    Objective: To determine the cost of using systemic therapy to treat newly diagnosed cytomegalovirus (CMV) retinitis in persons with AIDS. Design: Incidence-based simulation model of CMV treatment from a government payer perspective. Setting: Swiss healthcare system. Patients and participants:...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics