Causes of death and renal tubular dysfunction in residents exposed to cadmium in the environment

Nishijo, M.; Morikawa, Y.; Nakagawa, H.; Tawara, K.; Miura, K.; Kido, T.; Ikawa, A.; Kobayashi, E.; Nogawa, K.
August 2006
Occupational & Environmental Medicine;Aug2006, Vol. 63 Issue 8, p545
Academic Journal
Objectives: To clarify the causes of death of residents with renal tubular dysfunction induced by cadmium (Cd) in the environment. Methods: A 15 year follow up study was performed with the inhabitants living in the Cd polluted Kakehashi River basin in Japan. Standardised mortality ratios (SMRs) for causes of death, classified by ICD-9, were computed using the person-years method to investigate the excess mortality of subjects with urinary β2-MG (microglobulin) ⩾1000 μg/gCr. Mortality risk analysis was performed using Cox's proportional model to compare mortality between subjects with urinary β2-MG ⩾ 1000 and <1000 μg/gCr, and to investigate the relationship between the degree of urinary β2-MG and mortality. Results: Excess mortality due to heart failure and cerebral infarction in both sexes, and nephritis and nephrosis in men, was observed among subjects with urinary β2-MG ⩾1000 μg/gCr. Significant increases in mortality risk for cerebral infarction in men and for malignant neoplasms in women with urinary β2-MG ⩾ 1000 μg/gCr were observed during the first five year observation period. For nephritis and nephrosis, the mortality risks for men and women with urinary β2-MG ⩾ 1000 μg/gCr significantly increased over the 15 year observation period. The mortality risks for heart failure and cerebral infarction increased in proportion to the increased urinary β2-MG in both sexes. Increased mortality risks for nephritis and nephrosis were identified in the subjects with urinary β2-MG ⩾ 10000 μg/gCr in both sexes. Conclusion: Renal tubular dysfunction induced by Cd affected the causes of death, and mortality for heart failure, cerebral infarction, and nephritis and nephrosis was increased among inhabitants living in a Cd polluted area in Japan. In women, cancer mortality may have been increased while Cd pollution was ongoing.


Related Articles

  • Number of Deaths from 10 Leading Causes -- National Vital Statistics System, United States, 2010.  // MMWR Recommendations & Reports;3/1/2013, Vol. 62 Issue 8, p155 

    A chart is presented that lists 10 leading causes of number of deaths in the U.S. including Heart disease, Alzheimer's disease and Nephritis.

  • Diagnostic nuclear medicine in pediatric oncology-what we should know before scanning? Vlajković, Marina; Matović, Milovan // Archive of Oncology;2013, Vol. 21 Issue 2, p139 

    Cancer is second only to trauma as a cause of death in children, accounting for approximately 10% of all childhood deaths. The application of radioisotopes in the treatment of malignant diseases in children consists of detecting and estimating the degree of tumour spread by application of...

  • COULD THE CANCER-KILLING PLAGUE BE A MAGIC-BULLET? Makin, Simon // Guru;Apr/May2013, Issue 11, p18 

    The article reports that the JX-594, a genetically engineered for vaccinia virus, has been used to prolong the lives of people with terminal liver cancer, according to an article published in the February 2013 issue of the "Nature Medicine" journal. Results of a study published in 2011 showed a...

  • Eating red meat is associated with a sharply increased risk of death from cancer and heart disease, according to a new study, and the more of it you eat, the greater the risk.  // MondayMorning;3/19/2012, Vol. 20 Issue 12, p1 

    The article discusses a new study which reports an increased risk of death from cancer and heart disease due to the consumption of red meat. It informs that the online data published in the Archives of Internal Medicine supported the new research and stated that people consuming more red meat...

  • When good drugs go bad. Giacomini, Kathleen M.; Krauss, Ronald M.; Roden, Dan M.; Eichelbaum, Michel; Hayden, Michael R.; Nakamura, Yusuke // Nature;4/26/2007, Vol. 446 Issue 7139, p975 

    The author reflects on the ways to best reduce the risk of serious adverse drug reactions (SADR) to marketed drugs in the U.S. The author argues that although SADR are rare once a drug is marketed, they are considered to be the fourth leading cause of death in the country, not far behind cancer...

  • Leading Causes of Death among Asian American Subgroups (2003–2011). Hastings, Katherine G.; Jose, Powell O.; Kapphahn, Kristopher I.; Frank, Ariel T. H.; Goldstein, Benjamin A.; Thompson, Caroline A.; Eggleston, Karen; Cullen, Mark R.; Palaniappan, Latha P. // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Background: Our current understanding of Asian American mortality patterns has been distorted by the historical aggregation of diverse Asian subgroups on death certificates, masking important differences in the leading causes of death across subgroups. In this analysis, we aim to fill an...

  • Additive Effect of Anemia and Renal Impairment on Long-Term Outcome after Percutaneous Coronary Intervention. Pilgrim, Thomas; Rothenbühler, Martina; Kalesan, Bindu; Pulver, Cédric; Stefanini, Giulio G.; Zanchin, Thomas; Räber, Lorenz; Stortecky, Stefan; Jung, Simon; Mattle, Heinrich; Moschovitis, Aris; Wenaweser, Peter; Meier, Bernhard; Gsponer, Thomas; Windecker, Stephan; Jüni, Peter // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Introduction: Anemia and renal impairment are important co-morbidities among patients with coronary artery disease undergoing Percutaneous Coronary Intervention (PCI). Disease progression to eventual death can be understood as the combined effect of baseline characteristics and intermediate...

  • Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort. Adams, Scott V.; Passarelli, Michael N.; Newcomb, Polly A. // Occupational & Environmental Medicine;Feb2012, Vol. 69 Issue 2, p153 

    Objective This study examined prospective data from the Third National Health and Nutrition Examination Survey (NHANES III) cohort to investigate the relationship between cadmium exposure and cancer mortality, and the specific cancers associated with cadmium exposure, in the general population....

  • A morpho-molecular prognostic model for hepatocellular carcinoma. Srivastava, S; Wong, K F; Ong, C W; Huak, C Y; Yeoh, K G; Teh, M; Luk, J M; Salto-Tellez, M // British Journal of Cancer;7/10/2012, Vol. 107 Issue 2, p334 

    Background:Hepatocellular carcinoma (HCC) is the third common cause of cancer-related deaths and its prognostication is still suboptimal. The aim of this study was to establish a new prognostication algorithm for HCC.Methods:In all, 13 biomarkers related to the etiopathogenesis of HCC were...


Read the Article


Sign out of this library

Other Topics