TITLE

In vivo (animal) models of vein graft disease

AUTHOR(S)
Schachner, Thomas; Laufer, Günther; Bonatti, Johannes
PUB. DATE
September 2006
SOURCE
European Journal of Cardio-Thoracic Surgery;Sep2006, Vol. 30 Issue 3, p451
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Summary: Despite the very important use of arterial bypass conduits, vein grafts remain one cornerstone in coronary surgery. Newer studies show a saphenous vein graft patency of about 60% at 10 years postoperatively. This article reviews the in vivo (animal) models of vein graft disease. According to the different models, the findings on pathology of graft thrombosis, neointimal hyperplasia, and vein graft atherosclerosis are summarized. Therapeutic strategies to prevent vein graft disease (including external stenting, pharmacotherapy, and gene therapy) are reviewed.
ACCESSION #
21920244

 

Related Articles

  • The role of VEGF in normal and neoplastic hematopoiesis. Gerber, Hans-Peter; Ferrara, Napoleone // Journal of Molecular Medicine;Jan2003, Vol. 81 Issue 1, p20 

    VEGF is a secreted growth factor that mediates its biological effects by binding to two transmembrane tyrosine kinase receptors, VEGFR-1 and VEGFR-2. The VEGF/receptor signaling system is involved in the regulation of two fundamental processes in vertebrates: the formation of blood vessels...

  • Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HF-1 α) and the HIF-1 α target gene DEC1, but not lymph node metastasis..... Currie, M J; Hanrahan, V; Gunningham, S P; Morrin, H R; Framplon, C; Han, C; Robinson, B A; Fox, S B // Journal of Clinical Pathology;Aug2004, Vol. 57 Issue 8, p829 

    Background: Vascular endothelial growth factor D (VEGF-D) induces angiogenesis and lymphangiogenesis. Nodal metastasis is recognised as a powerful prognostic marker in breast carcinoma, but the molecular mechanisms underlying this process are unknown. Although it has been suggested that VEGF-D...

  • The Split Radial Technique: An Alternative to the Y-Graft for Total Arterial Myocardial Revascularisation Esmore, Donald S.; Markman, Phuong L.; Agrawal, Sunil; Burton, Paul R.; Rosenfeldt, Franklin L. // Heart, Lung & Circulation;Mar2005, Vol. 14 Issue 1, p32 

    There is evidence that the use of Y-grafts attached to the left internal mammary artery – to – left anterior descending artery graft may compromise the patency of the distal limb of the left internal mammary artery. We describe a technique (split radial technique) that avoids the...

  • Endovascular Treatment of Traumatic Thoracic Aortic Rupture Combined with Diaphragmatic Rupture A Case Report. Zeebregts, Clark J.; Klaase, Joost M.; Geelkerken, Robert H. // Vascular & Endovascular Surgery;May/Jun2003, Vol. 37 Issue 3, p219 

    The purposes of this report are to describe the immediate repair of a diaphragmatic rupture and subsequent endovascular treatment of a thoracic aortic rupture secondary to blunt chest and abdominal trauma and to discuss the outcome in the light of the trauma scores. A 29year-old man was injured...

  • Endovascular Treatment for Traumatic Rupture of Descending Thoracic Aorta. Castelli, P.; Caronno, R.; Lagan�, D.; Beretta, R.; Piffaretti, G.; Tozzi, M. // Internet Journal of Thoracic & Cardiovascular Surgery;2003, Vol. 6 Issue 1, p4 

    Introduction: Traumatic rupture of the descending thoracic aorta typically involves the isthmus (85%); just the 15-20% of the patients survive the trauma. The endovascular approach may represent an effectiveness alternative therapy to traditional surgical treatment. Materials and method: In the...

  • Endovascular Management of an Aortobronchial Fistula Arising After Resection of a Primary Aortic... Caiati, Joseph M.; Matin, Michael L.; Flores, Raja M.; Smith, Craig R.; Martin, Eric C.; Todd, George J. // Vascular Surgery;Jan/Feb2001, Vol. 35 Issue 1, p73 

    Reports on a patient who have previously undergone resection of a thoracic aortic sarcoma and subsequently presented in extremis from an aortobronchial fistula. Use of endovascular covered stents for aortic lesions; Evaluation and treatment of an aortic sarcoma and the successful urgent...

  • PATHOGENESIS OF EXPERIMENTAL TRAUMATIC THORACIC ANEURYSM. Moffat, Robert C.; Knechtges, Thomas C.; Roberts, Verne L.; Berkas, Ernest M. // Vascular Surgery;Apr1967, Vol. 1 Issue 1, p11 

    Traumatic thoracic aneurysms resulted in the dog following blunt trauma to the thorax. The pathogenesis of such lesions was demonstrated. The initial lesion was observed to be a transverse tear involving; the inner layers of the vessel. The resulting lesions were false aneurysms which were...

  • Fine Structures Around the Orifice of the Intercostal Artery of the Rabbit Thoracic Aorta. Emura, Sei; Masuko, Sadahiko; Sunaga, Toshiaki // Angiology;Mar1992, Vol. 43 Issue 3P1, p211 

    In hypercholesterolemic rabbits, atherosclerotic lesions easily occur in the thoracic aorta, especially at the distal and lateral sides of the walls around the orifices of the dorsal intercostal arteries. In order to examine whether some special structures that lead to atherosclerotic lesions...

  • Aortic valve replacement following previous coronary surgery. Shanmugam, Ganesh // European Journal of Cardio-Thoracic Surgery;Nov2005, Vol. 28 Issue 5, p731 

    Summary: Aortic valve replacement following previous coronary surgery is associated with high risk. Major intraoperative problems include those associated with reentry, damage to the left internal mammary artery and myocardial protection. These factors influence operative results and eventual...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics