TITLE

Molecular characterisation of non-absorptive and absorptive enterocytes in human small intestine

AUTHOR(S)
Gassler, N.; Newrzella, D.; Böhm, C.; Lyer, S.; Li, L.; Sorgenfrei, O.; van Laer, L.; Sido, B.; Mollenhauer, J.; Poustka, A.; Schirmacher, P.; Gretz, N.
PUB. DATE
August 2006
SOURCE
Gut;Aug2006, Vol. 55 Issue 8, p1084
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: Perturbation of differentiation of the crypt-villus axis of the human small intestine is associated with several intestinal disorders of clinical importance. At present, differentiation of small intestinal enterocytes in the crypt-villus axis is not well characterised. Subjects and methods: Expression profiling of microdissected enterocytes lining the upper part of crypts or the middle of villi was performed using the Affymetrix X3P arrays and several methods for confirmation. Results: A total of 978 differentially expressed sequences representing 778 unique UniGene IDs were found and categorised into four functional groups. In enterocytes lining the upper part of crypts, cell cycle promoting genes and transcription/translation related genes were predominantly expressed, whereas in enterocytes lining the middle of villi, high expression of cell cycle inhibiting genes, metabolism related genes, and vesicle/transport related genes was found. Conclusion: Two types of enterocytes were dissected at the molecular level, the non-absorptive enterocyte located in the upper part of crypts and the absorptive enterocyte found in the middle of villi. These data improve our knowledge about the physiology of the crypt-villus architecture in human small intestine and provide new insights into pathophysiological phenomena, such as villus atrophy, which is clinically important.
ACCESSION #
21843675

 

Related Articles

  • Small bowel obstruction due to an impacted endoscopy capsule. Levsky, Jeffrey M.; Milikow, David L.; Rozenblit, Alla M.; Wolf, Ellen L. // Abdominal Imaging;Sep/Oct2008, Vol. 33 Issue 5, p579 

    Capsule endoscopy (CE), a recently introduced technology, offers important benefits for evaluation of small bowel pathology as compared to traditional radiologic and endoscopic studies. The most striking complication of this modality is capsule retention, which may obligate invasive retrieval....

  • Cuboidal calcium enterolith causing obstruction and perforation of small intestine.  // British Medical Journal (Clinical Research Edition);2/18/1984, Vol. 288 Issue 6416, p532 

    Examines a case of cuboidal calcium enterolith in a 56-year old patient. Complaints of the patient; Radiographic findings; Development of the disorder in the distal small bowel.

  • enteric disease:. Huber, Jeffrey T.; Gillaspy, Mary L. // Encyclopedic Dictionary of AIDS-Related Terminology;2000, p83 

    A definition of the term "enteric disease," which refers to any pathological condition involving the small intestine, is presented.

  • Bevacizumab.  // Reactions Weekly;3/31/2012, Issue 1395, p10 

    The article describes the case of a 53-year-old woman with metastatic breast cancer who developed small bowel perforation while receiving bevacizumab.

  • Idiopathic Pneumatosis Intestinalis of the Small Intestine. Anne, Nirupama; Rajput, Ashwani; Dunn, Kelli; Litwin, Alan // American Surgeon;Nov2008, Vol. 74 Issue 11, p1127 

    A letter to the editor is presented about the case of a 63-year old man who had idiopathic pneumatosis intestinalis of the small intestine.

  • Eosinophilic Enteritis presenting as Acute Intestinal Obstruction. Malik, Sikandar Ali; Yasin, Malik Amjad; Nasreen, Ghazala // Internet Journal of Surgery;2008, Vol. 15 Issue 2, p6 

    Study design: A case report Objectives: To describe an unusual presentation of a rare disease Setting: Department of General Surgery, Military Hospital Rawalpindi 4600, Pakistan. Methods: A 37-year-old female with history of chronic abdominal pain presented with acute intestinal obstruction....

  • Immunoproliferative Small Intestinal Disease. Swaroop, V. Santhi // American Journal of Gastroenterology;Mar2000, Vol. 95 Issue 3, p848 

    Presents a letter to the editor in response to the article "A Heavy Chain Disease, Mediterranean Lymphoma and Immunoproliferative Small Intestinal Disease. A Review of Clinicopathological Features," by K. D. Fine and M. J. Stone in the 1999 issue.

  • Peritoneal Encapsulation of the Small Bowel: A Rare Cause of Intestinal Obstruction. Awasthi, S.; Saraswat, V. A.; Kapoor, V. K. // American Journal of Gastroenterology;Mar1991, Vol. 86 Issue 3, p383 

    Presents a letter to the editor on peritoneal encapsulation of the small bowel.

  • Study examining large-scale data of double balloon enteroscopy shows it is safe and effective.  // Biomedical Market Newsletter;9/30/2011, Vol. 21, p409 

    The article focuses on a study which suggests the safety and effectiveness of double balloon enteroscopy (DBE) for detecting diseases in small intestines.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics