Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease

Kawada, N.
August 2006
Gut;Aug2006, Vol. 55 Issue 8, p1073
Academic Journal
The article discusses the role of hepatic stellate cells (HSCs) in human liver fibrosis. In the liver, HSCs occupy the space between sinusoids and hepatocytes. They help to regulate sinusoidal blood flow, and store lipid droplets containing vitamin A. When an injury is caused in the liver parenchyma due to various reasons, such as excessive iron, or alcohol consumption, hepatocytes are eliminated, due to which HSCs detach from the sinusoidal wall and become activated.


Related Articles

  • Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways. Qiong LIU; Jing CHEN; Xu WANG; Liang YU; Li-hong HU; Xu SHEN // Acta Pharmacologica Sinica;Aug2010, Vol. 31 Issue 8, p944 

    AbstractAim:To investigate the effects of the natural product Withagulatin A on hepatic stellate cell (HSC) viability and type I procollagen production. The potential mechanism underlying the pharmacological actions was also explored.Methods:The effect of Withagulatin A on cell viability was...

  • Molecular mechanism of stellate cell activation and therapeutic strategy for liver fibrosis. Kawada, Norifumi // Comparative Hepatology;2004 Supplement 1, Vol. 3, pS3 

    A conference paper about the molecular mechanisms of stellate cell activation and therapeutic strategy for liver fibrosis is presented. It isolates a novel protein dabbed STAP after stellate cell activation-associated protein and clones its cDNA. It also presents several studies that show a...

  • Scintigraphic study of regenerative nodules due to fulminant hepatic failure. Watabe, Tomohiro; Kondo, Masahiko; Hirasa, Masahiro; Shirane, Hirofumi; Okabe, Yoshihiro; Ibuki, Yasuyoshi; Tomita, Shusuke; Orino, Akio; Todo, Akio; Wakatsuki, Yoshio; Chiba, Tsutomu; Kudo, Masatoshi // Journal of Gastroenterology;2003, Vol. 38 Issue 7, p695 

    Discusses the case a 25-year-old female patient with fulminant hepatic failure. Assessment of liver function using [sup 99m]Tc-galactosyl human serum albumin; Status of hepatocytes in regenerative nodules; Impairment of Kupffer cells.

  • Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. Li, Jing-Ting; Liao, Zhang-Xiu; Ping, Jie; Xu, Dan; Wang, Hui // Journal of Gastroenterology;2008, Vol. 43 Issue 6, p419 

    Activation of hepatic stellate cells (HSCs) is the dominant event in liver fibrosis. The early events in the organization of HSC activation have been termed initiation. Initiation encompasses rapid changes in gene expression and phenotype that render the cells responsive to cytokines and other...

  • Hepatic Stellate Cells and Liver Fibrosis. Moreira, Roger Klein // Archives of Pathology & Laboratory Medicine;Nov2007, Vol. 131 Issue 11, p1728 

    Substantial evidence now exists to recognize hepatic stellate cells (HSCs) as the main matrix-producing cells in the process of liver fibrosis. Liver injury of any etiology will ultimately lead to activation of HSCs, which undergo transdifferentiation to fibrogenic myofibroblast-like cells....

  • The regulatory role of prostaglandin E2 in liver (patho) physiology is controlled at its site of synthesis and its action on the receptors. Dieter, Peter; Scheibe, Roland; Bezugla, Yefgeniya; Matthé, Egbert; Schuch, Sandra; Treffkorn, Lars; Bernard, Brigitte; Kamionka, Sabine; Kolada, Angelika // Comparative Hepatology;2004 Supplement 1, Vol. 3, p1 

    A conference paper about the regulatory role of prostaglandin E (PGE)2 in liver pathophysiology is presented. It isolates liver nonparenchymal cells from male rat livers by a progenase/collagenase perfusion. It characterizes isolated liver nonparenchymal cells by different markers. It concludes...

  • 5-Lipoxygenase (5-LO) is Involved in Kupffer Cell Survival. Possible Role of 5-LO Products in the Pathogenesis of Liver Fibrosis. Titos, Esther; Planagumà, Anna; López-Parra, Marta; Villamor, Neus; Miquel, Rosa; Jiménez, Wladimiro; Arroyo, Vicente; Rivera, Francisca; Rodés, Joan; Clària, Joan // Comparative Hepatology;2004 Supplement 1, Vol. 3, pS19 

    A conference paper about the 5-lipoxygenase (5-LO) pathway in sinusoidal liver cells and the role of 5-LO in Kupffer cell growth and survival is presented. Results reveal that 5-LO plays a vital role in cell proliferation and survival and establishes basis for the application of 5-LO inhibitors...

  • A deer in the headlights: BAMBI meets liver fibrosis. Friedman, Scott L. // Nature Medicine;Nov2007, Vol. 13 Issue 11, p1281 

    The article presents a study conducted by E. Seki et al. which examines the fibrogenic signaling through Toll-like receptor 4 (TLR4) in hepatic stellate cells and the role of Kupffer cells. Researchers found that lipopolysaccharide starts a signaling flow in stellate cells that leads to...

  • Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation. Hong Shen; Manna Zhang; Minuk, Gerald Y.; Yuewen Gong // BMC Cell Biology;2002, Vol. 3, p9 

    Background: Liver fibrosis is the common sequel of chronic liver diseases. Recent studies have identified hepatic stellate cells as the primary cell type mediating hepatic fibrogenesis. It has been demonstrated that hepatic stellate cells undergo a process of activation during the development of...


Read the Article


Sign out of this library

Other Topics