TITLE

Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease

AUTHOR(S)
Kawada, N.
PUB. DATE
August 2006
SOURCE
Gut;Aug2006, Vol. 55 Issue 8, p1073
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the role of hepatic stellate cells (HSCs) in human liver fibrosis. In the liver, HSCs occupy the space between sinusoids and hepatocytes. They help to regulate sinusoidal blood flow, and store lipid droplets containing vitamin A. When an injury is caused in the liver parenchyma due to various reasons, such as excessive iron, or alcohol consumption, hepatocytes are eliminated, due to which HSCs detach from the sinusoidal wall and become activated.
ACCESSION #
21843672

 

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