Significance of anti-inflammatory effects of PPARγ agonists?

Rogler, G.
August 2006
Gut;Aug2006, Vol. 55 Issue 8, p1067
Academic Journal
The article discusses the use of peroxisome proliferator activated receptor γ (PPARγ) for the treatment of colitis, and maintaining homeostasis of the mucosal barrier in intestines. PPARγ ligands have been found to reduce mucosal damage, and reduce intestinal inflammation. Thiazolidinediones are synthetic ligands of PPARγ and help in reduction of inflammation in intestines. PPARγ is also useful in treatment of colon cancer.


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