TITLE

Pathophysiological basis of CNS injury in cardiac surgical patients: detection and prevention

AUTHOR(S)
Murkin, John M.
PUB. DATE
July 2006
SOURCE
Perfusion;Jul2006, Vol. 21 Issue 4, p203
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The current understanding of adverse central nervous system (CNS) events following cardiac surgery involves several identifiable, evidence-based mechanisms: atherosclerotic emboli, microgaseous and microparticulate emboli, and hypoperfusion. Secondary factors, including patient co-morbidities and inherent genetic susceptibilities, as well as systemic inflammatory processes and a suboptimal metabolic milieu may interact to potentiate the extent of injury. In this review a number of these factors and their potential interactions will be explored with a view towards developing a comprehensive management strategy to minimize CNS injury.
ACCESSION #
21783202

 

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