Genome complexity, robustness and genetic interactions in digital organisms

Lenski, Richard E.; Ofria, Charles; Collier, Travis C.; Adami, Christoph
August 1999
Nature;8/12/1999, Vol. 400 Issue 6745, p661
Academic Journal
Presents an experiment with digital organisms to show the role of genetic interactions in complex organisms. Development of digital organisms; Simple computer programs for rapid replication and complex programs to perform mathematical operations that accelerate replication through a set of defined metabolic rewards; Examination of the differences in genetic architecture; Methods; Results; Interpretation.


Related Articles

  • Macroevolution simulated with autonomously replicating computer programs. Yedid, Gabriel; Bell, Graham // Nature;12/19/2002-12/26/2002, Vol. 420 Issue 6917, p810 

    The process of adaptation occurs on two timescales. In the short term, natural selection merely sorts the variation already present in a population, whereas in the longer term genotypes quite different from any that were initially present evolve through the cumulation of new mutations. The first...

  • Parametric Stability Analyses in Field Pea (Pisum sativum L.) under South Eastern Ethiopian Condition. Fikere, Mulusew; Fikiru, Edossa; Tadesse, Tadele; Legesse, Teshome // World Journal of Agricultural Sciences;Mar2009, Vol. 5 Issue 2, p146 

    Genotype-environment Interaction (GEI) has been important and challenging issue for plant breeders in developing improved varieties. Several biometrical methods are available for analysis of G-E interaction and yield stability. Grain yield of 16 field pea (Pisum sativum L.) genotypes tested in a...

  • Novel Rank-Based Approaches for Discovery and Replication in Genome-Wide Association Studies. Chia-Ling Kuo; Zaykin, Dmitri V. // Genetics;Sep2011, Vol. 189 Issue 1, p329 

    In recent years, genome-wide association studies (GWAS) have uncovered a large number of susceptibility variants. Nevertheless, GWAS findings provide only tentative evidence of association, and replication studies are required to establish their validity. Due to this uncertainty, researchers...

  • 'Validation' in genome-scale research.  // Journal of Biology;2008, Vol. 8, p104 

    The individual ‘validation’ experiments typically included in papers reporting genome-scale studies often do not reflect the overall merits of the work.

  • Gene Expression Programming and One-Dimensional Chaotic Maps. Hardy, Yorick; Steeb, W.-H. // International Journal of Modern Physics C: Computational Physics;Jan2002, Vol. 13 Issue 1, p13 

    Gene expression programming is applied to find one-dimensional maps. A survey on gene expression programming is also given.

  • Image Mosaic based on Cloud Model Cellular Automata. Li Xinhua // International Journal of Signal Processing, Image Processing & P;Dec2013, Vol. 6 Issue 6, p179 

    Owing to the fact that fabric images exhibit strong periodic and their features are difficult to extract, an image mosaic method based on cloud model cellular automata is presented. The edge feature points from two images are extracted by cloud model cellular automata, and then the corresponding...

  • LRRK2 R1628P increases risk of Parkinson’s disease: replication evidence. Tan, E. K.; Tan, Louis C.; Lim, H. Q.; Li, R.; Tang, M.; Yih, Yuen; Pavanni, R.; Prakash, K. M.; Fook-Chong, S.; Zhao, Yi // Human Genetics;Oct2008, Vol. 124 Issue 3, p287 

    We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson’s disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1–5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset,...

  • Butterfly effect.  // Engineer (00137758);5/24/2010, Vol. 295 Issue 7795, p16 

    The article reports on the success of a group of Japanese researchers in building a fully functional replica model of a swallowtail butterfly, which is designed for future aerodynamic systems.

  • Replications in the finance literature: An empirical study. Hubbard, Raymond; Vetter, Daniel E. // Quarterly Journal of Business & Economics;Autumn91, Vol. 30 Issue 4, p70 

    Presents information about replication of published findings in finance literature. Publication frequency of replications/extensions in finance; Publication frequency of replications/extensions 1969-1982 versus 1983-1989; Previous findings; Additional checks on the accuracy of published...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics