Elastin fragments are pro-inflammatory in the progression of emphysema

Aggarwal, Y.
July 2006
Thorax;Jul2006, Vol. 61 Issue 7, p567
Academic Journal
The article presents an abstract of the study conducted by A. M. Houghton, P. A. Quintero, D. L. Perkins and others published in another journal. The study was about the role of elastin fragments in the progression of emphysema which uses animal model to investigate such mechanism. Based on the study, exposure to chronic cigarette smoking activates alveolar macrophage and eventual release of matrix metalloproteinase-12 (MMP-12) which produces elastin fragments.


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