Lowering homocysteine with folic acid and B vitamins did not prevent vascular events in vascular disease: COMMENTARY

Shekelle, Paul
July 2006
ACP Journal Club;Jul/Aug2006, Vol. 145 Issue 1, p2
Academic Journal
The article presents the author's views regarding the dramatic effect of simple and cheap pills in cardiovascular diseases (CV). The first trial was performed on 3680 patients in which a high-dose combination of B vitamins and folate with a control pill of low doses were given to the patients. The speculation was that taking the pill will decrease the plasma levels of homocysteine and will help to reduce the CV events. In spite of an increase in blood levels of folate and B vitamins their was no effect on stroke in the patients.


Related Articles

  • Plasma homocysteine, folate and vitamin B12 levels in psychiatric patients: preliminary data. Katsigiannopoulos, Konstantinos; Pazarlis, Pandelis; Aliki, Ioakimidou; Triantafyllidou, Efthimia; Kleta, Drossia; Mastrogianni, Anastasia; Karastergiou, Anastasia; Makrigiannaki, Eleni // Annals of General Psychiatry;2006 Supplement 1, Vol. 5, pS146 

    A conference paper about plasma homocysteine, folate and vitamin B12 levels in psychiatric patients is presented. Results reveal an elevated homocysteine levels in the subgroup of the schizophrenic patients. The mean plasma folate level was also elevated in the same group, and significantly...

  • Immediate and long-term high levels of plasma homocysteine after extracorporeal shock wave lithotripsy in patients with renal stone disease. Demir, Erkan; Izol, Volkan; Aridogan, I.; Paydas, Saime; Tansug, Zuhtu; Erken, Ugur // Clinical & Experimental Nephrology;Aug2014, Vol. 18 Issue 4, p623 

    Background: Plasma homocysteine levels increase in patients with chronic renal failure. Numerous studies have demonstrated that kidney function is one of the most important determinants of plasma total homocysteine (tHcy) concentration. In this study we aimed to evaluate the relationship between...

  • Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease. Hadithi, Muhammed; Mulder, Chris J. J.; Stam, Frank; Azizi, Joshan; Crusius, J. Bart A.; Peña, Amado Salvador; Stehouwer, Coen D. A.; Smulders, Yvo M.; Dickey, William // World Journal of Gastroenterology;2/28/2009, Vol. 15 Issue 8, p955 

    AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men,...

  • Elevated concentrations of plasma homocysteine in coronary artery disease patients with normal folate level. Baby, Bejoy; Saravanan, G.; Chinnaswamy, P. // Journal of Pharmaceutical Sciences & Research;Jun2009, Vol. 1 Issue 2, p51 

    Hyperhomocysteinemia is becoming a growing concern as a risk factor in patients suffering from coronary artery disease. The purpose of our study was to evaluate the existence of hyperhomocysteinemia with folate levels along with conventional risk factors. A total of 80 cases (50 patients and 30...

  • Cardiovascular disease: Homocysteine, folate, methylenetetrahydrofolate reductase genotype and vascular morbidity in diabetic subjects. Day, Andrew // Annals of Clinical Biochemistry;Nov2002, Vol. 39 Issue 6, p625 

    The article reports on the study regarding homocysteine, folate, methylenetetrahydrofolate reductase genotype and vascular morbidity in diabetics. The study confirms an association between hyperhomocysteinaemia and vascular disease, although the overall prevalence of hyperhomocysteinaemia was...

  • Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India. Deshmukh, U. S.; Joglekar, C. V.; Lubree, H. G.; Ramdas, L. V.; Bhat, D. S.; Naik, S. S.; Hardikar, P. S.; Raut, D. A.; Konde, T. B.; Wills, A. K.; Jackson, A. A.; Refsum, H.; Nanivadekar, A. S.; Fall, C. H.; Yajnik, C. S. // European Journal of Clinical Nutrition;May2010, Vol. 64 Issue 5, p495 

    Background/Objectives:Vitamin B12 (B12) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B12 and...

  • Hyperhomocysteinemia and the role of B vitamins in cancer. Plazar, Nadja; Jurdana, Mihaela // Radiology & Oncology;2010, Vol. 44 Issue 2, p79 

    Background. Patients suffering from malignancies have increased complications due to corresponding cardiovascular diseases and risk factor for the development of venous thromboembolism. Epidemiological studies have shown that increased homocysteine plasma concentration (hyperhomocysteinemia) is...

  • Association between Helicobacterpylori-infection, C-reactive protein and status of B vitamins. Stettin, D.; Waldmann, A.; Ströhl, A.; Hahn, A. // Advances in Medical Sciences (De Gruyter Open);2008, Vol. 53 Issue 2, p205 

    Purpose: Some investigations, but not all, found that a chronic infection with Helicobacter pylori (Hp) is associated with deficiencies in B vitamins, elevated plasma total homocysteine concentrations (tHcy) and increased plasma levels of proinflammatory acute-phase proteins. It has been...

  • B-lieve it. Snyder, Karyn // Drug Topics;9/15/97, Vol. 141 Issue 18, p53 

    Focuses on researches which indicate that a diet low in animal protein and high in vitamin B is essential in heart attack prevention. Information on the believe that vitamins B6, B12 and folic acid may counter homocysteine's damaging effect on arteries; Reference to a profile of Kilmer McCully...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics