TITLE

Predictive factors of stroke in patients undergoing coronary bypass grafting: statins are protective

AUTHOR(S)
Aboyans, Victor; Labrousse, Louis; Lacroix, Philippe; Guilloux, Jérôme; Sekkal, Seifeddine; Le Guyader, Alexandre; Cornu, Elisabeth; Laskar, Marc
PUB. DATE
August 2006
SOURCE
European Journal of Cardio-Thoracic Surgery;Aug2006, Vol. 30 Issue 2, p300
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract: Background: Despite major improvement in surgical techniques and intensive care management, stroke remains one of the most devastating complications of coronary artery bypass grafting (CABG). We aimed to determine factors predicting the occurrence of stroke during CABG. A special interest was focused on preoperative therapies. Methods: We prospectively enrolled 810 consecutive candidates for CABG alone in a specific database, including all pre- and perioperative data (history, clinical, therapeutic, cardiac catheterization, surgical and intensive care data). Univariate tests and then multiple logistic regression analysis were used to determine independent predictive factors. Results: During the first postoperative month, stroke occurred in 11 cases and transient ischemic attack (TIA) in 4 additive cases (cumulative rate: 1.85%). After the multivariate analysis, the following factors remained significant (p <0.05) in the predictive model, with corresponding odds ratios between brackets: redo cardiac surgery (7.45), unstable cardiac status (4.74), past history of cerebrovascular disease (4.14), past history of peripheral arterial disease (3.55), whereas the presence of preoperative statins was protective (0.24, 95% IC: 0.07–0.78). The addition of perioperative data (aortic calcification, postoperative arrhythmia, on/off-pump surgery) did not change the final predictive model. Conclusion: To our knowledge, this is the first real-world observational report highlighting the interest of statins for the prevention of stroke in the very special situation of CABG. Even though according to randomized trials coronary patients have a benefit from these drugs, a special level of interest should be directed towards those presenting the above-mentioned risk factors.
ACCESSION #
21665227

 

Related Articles

  • Statin Therapy for Vascular Failure. Teruo Inoue; Koichi Node // Cardiovascular Drugs & Therapy;Aug2007, Vol. 21 Issue 4, p281 

    Abstract  There is increasing evidence that statins reduce cardiovascular events such as coronary artery disease or stroke in hypercholesterolemic patients in both primary and secondary prevention. The striking benefit achieved with statin treatments in patients with a wide range...

  • A Multidisciplinary Approach to Unplanned Conversion from Off-Pump to On-Pump Beating Heart Coronary Artery Revascularization in Patients with Compromised Left Ventricular Function. Tsaousi, Georgia; Pitsis, Antonis A.; Ioannidis, George D.; Vasilakos, Dimitrios G. // Critical Care Research & Practice;2014, p1 

    Aim. To comparably assess the perioperative risk factors that differentiate off-pump coronary artery bypass (OPCAB) grafting cases from those sustaining unplanned conversion to on-pump beating heart (ONCAB/BH) approach, in patients with left ventricular ejection fraction (LVEF) < 40%. Methods....

  • Neurocognitive Function after Coronary-Artery Bypass Surgery. Mack, Michael J.; Magee, Mitchell J.; Dewey, Todd M. // New England Journal of Medicine;8/16/2001, Vol. 345 Issue 7, p543 

    A letter to the editor is presented in response to the February 8, 2001 article by Mark F. Newman, entitled "Longitudinal Assessment of Neurocognitive Function After Coronary-Artery Bypass Surgery."

  • Neurocognitive Function after Coronary-Artery Bypass Surgery. Aklog, Lishan // New England Journal of Medicine;8/16/2001, Vol. 345 Issue 7, p543 

    A letter to the editor is presented in response to the February 8, 2001 article by Mark F. Newman, entitled "Longitudinal Assessment of Neurocognitive Function After Coronary-Artery Bypass Surgery."

  • Neurocognitive Function after Coronary-Artery Bypass Surgery. Wilner, Asher P. // New England Journal of Medicine;8/16/2001, Vol. 345 Issue 7, p543 

    A letter to the editor is presented in response to the February 8, 2001 article by Mark F. Newman, entitled "Longitudinal Assessment of Neurocognitive Function After Coronary-Artery Bypass Surgery."

  • Neurocognitive Function after Coronary-Artery Bypass Surgery. Malphurs, Julie E.; Roscoe, Lori A. // New England Journal of Medicine;8/16/2001, Vol. 345 Issue 7, p543 

    A letter to the editor is presented in response to the February 8, 2001 article by Mark F. Newman, entitled "Longitudinal Assessment of Neurocognitive Function After Coronary-Artery Bypass Surgery."

  • Neurocognitive Function after Coronary-Artery Bypass Surgery. Taggart, D.P.; Browne, S.M.; Halligan, P.W. // New England Journal of Medicine;8/16/2001, Vol. 345 Issue 7, p543 

    A letter to the editor is presented in response to the February 8, 2001 article by Mark F. Newman, entitled "Longitudinal Assessment of Neurocognitive Function After Coronary-Artery Bypass Surgery."

  • Neurocognitive Function after Coronary-Artery Bypass Surgery. Newman, Mark F.; Blumenthal, James A. // New England Journal of Medicine;8/16/2001, Vol. 345 Issue 7, p543 

    A response by Mark F. Newman and James A. Blumenthal to the letters to the editor about their February 8, 2001 article "Longitudinal Assessment of Neurocognitive Function After Coronary-Artery Bypass Surgery" is presented.

  • Fast track recovery of high risk coronary bypass surgery patients. Alhan, Cem; Toraman, Fevzi; Karabulut, Esref Hasan; Tarcan, Sümer; Dağdelen, Sinan; Eren, Nevnihal; Cağlar, Nuri // European Journal of Cardio-Thoracic Surgery;May2003, Vol. 23 Issue 5, p678 

    Objective: Fast track recovery protocols on younger, low risk patients result in shorter hospital stays and decreased costs. However, data is lacking on the impact of these protocols on high risk patients based on an objective scoring system. Methods: In this study, a high risk cohort of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics