TITLE

Usefulness of Tc99m HMPAO Labeled Leukocyte Scintigraphy in differentiating Splenic Abscess from Infarct

AUTHOR(S)

Vijayakumar, Vani; Briscoe, Elma G.

PUB. DATE

July 2006

SOURCE

Internet Journal of Nuclear Medicine;2006, Vol. 3 Issue 1, p3

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Radionuclide labeled leukocyte studies are routinely performed in the evaluation of patients with fever of unknown origin and occult infections. Cerebral perfusion agent Tc99m hexamethylpropyleneamine oxime (Tc99m - HMPAO) is one of the radiopharmaceuticals widely used for labeling of mixed leukocytes. It is a lipophilic agent which crosses cell membranes readily and preferentially labels granulocytes. This mechanism is used for labeling of leukocytes. Tc99m labeled leukocytes normally accumulate in spleen by sequestration. At sites of acute infection, focal increased radiotracer labeled leukocyte uptake is seen. Hence, focal defects in spleen represent infarcts. We present in this report two cases of splenic infarct diagnosed by Tc99m HMPAO labeled leukocytes.

ACCESSION #

21641326

Tags: SPLEEN -- Diseases -- Diagnosis;  INFARCTION;  DIAGNOSTIC imaging;  OXIMES;  LEUCOCYTES;  EMISSION tomography

 

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