Isolation and cultivation of neuronal precursor cells from the developing human enteric nervous system as a tool for cell therapy in dysganglionosis

Rauch, Ulrich; Hänsgen, Andrea; Hagl, Cornelia; Holland-Cunz, Stefan; Schäfer, Karl-Herbert
November 2006
International Journal of Colorectal Disease;Nov2006, Vol. 21 Issue 6, p554
Academic Journal
The article presents a study which investigated if isolation and cultivation of neuronal precursor cells from the developing human enteric nervous system (ENS) can serve as a tool for cell therapy in dysganglionosis. A way to isolate and expand precursor cells from the developing and postnatal human ENS was established. Results revealed that enteric neurospheres could be grown from different gestational ages, including postmortem material.


Related Articles

  • Ocular oscillations generated by coupling of brainstem excitatory and inhibitory saccadic burst neurons. Ramat, Stefano; Leigh, R. John; Zee, David S.; Optican, Lance M. // Experimental Brain Research;Jan2005, Vol. 160 Issue 1, p89 

    The human saccadic system is potentially unstable and may oscillate if the burst neurons, which generate saccades, are not inhibited by omnipause neurons. A previous study showed that combined saccade vergence movements can evoke oscillations in normal subjects. We set out to determine: 1)...

  • Polyglycolic acid filaments guide Schwann cell migration in vitro and in vivo. Wen Hu; Jianhui Gu; Aidong Deng; Xiaosong Gu // Biotechnology Letters;Nov2008, Vol. 30 Issue 11, p1937 

    Nerve conduits filled with longitudinal aligned filaments have demonstrated a better regenerative outcome for bridging large peripheral nerve gaps than hollow nerve conduits. In the present study, we investigated the in vitro and in vitro cellular behavior of Schwann cells on polyglycolic acid...

  • Specifying nociceptors. Markus, Annette // Nature Neuroscience;Feb2006, Vol. 9 Issue 2, p162 

    The article examines the characteristics of sensory neurons in peripheral sensory ganglia. Subgroups of sensory neurons specialize in distinct sensory modalities, such as proprioception, nociception, heat, cold or touch. They differ in size, their projection areas, their degree of myelination,...

  • A master regulator of nociceptor differentiation. Markus, Annette // Nature Neuroscience;Nov2008, Vol. 11 Issue 11, p1246 

    The article discusses the study on the significance of the transcription factor Islet1 on sensory neuron development. It is noted that the authors genetically excised Islet1 from the early mouse neural crest and dorsal neural tube, where the dorsal root and trigeminal ganglia formed normally but...

  • Motor program initiation and selection in crickets, with special reference to swimming and flying behavior. Matsuura, Tetsuya; Kanou, Masamichi; Yamaguchi, Tsuneo // Journal of Comparative Physiology A: Neuroethology, Sensory, Neu;Jan2002, Vol. 187 Issue 12, p987 

    An air puff stimulus to the cerci of a cricket (Gryllus bimaculatus) evokes flying when it is suspended in air, while the same stimulus evokes swimming when it is placed on the water surface. After bilateral dissection of the connectives between the suboesophageal and the prothoracic ganglia or...

  • ganglion:. Huber, Jeffrey T.; Gillaspy, Mary L. // Encyclopedic Dictionary of AIDS-Related Terminology;2000, p96 

    The article presents an encyclopedia entry for ganglion. It refers to a collection of nerve cells found outside of the central nervous system. The term can also be referred to as benign cystic tumor that developed on a tendon. Another location of the tumor is in the back portion of the wrist or...

  • Mechanical stimulation and B2 but not Bi receptor agonist lead to Ca2+ increase in sensory neurons.  // Pflugers Archiv European Journal of Physiology;Apr2000 Supplement, Vol. 439, pR336 

    The article presents the abstract of the study "Mechanical Stimulation and B2 but not B1 Receptor Agonist Lead to Ca2+ Increase in Sensory Neurons." It investigates the cellular level whether functional B1 receptors are induced, and whether functional B2 receptors are upregulated in dorsal root...

  • Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons. Street, Sarah E; Zylka, Mark J // Neuropsychopharmacology;Jan2011, Vol. 36 Issue 1, p358 

    The article cites a research study that analyzes the role of ectonucleotidases in nociceptive neurons. It is said that painful stimuli can be detected by nociceptive neurons located in the dorsal root ganglia. Noxious thermal and mechanical sensitization that are associated with chronic pain can...

  • polyganglionic.  // Taber's Cyclopedic Medical Dictionary;2005, p1725 

    A definition of the term "polyganglionic" is presented. It refers to the practice of having many ganglia.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics