TITLE

Impedimetric genosensors for the detection of DNA hybridization

AUTHOR(S)
Bonanni, A.; Esplandiu, M. J.; Pividori, M. I.; Alegret, S.; Del Valle, M.
PUB. DATE
September 2006
SOURCE
Analytical & Bioanalytical Chemistry;Sep2006, Vol. 385 Issue 7, p1195
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Impedance spectroscopy is proposed as the transduction principle for detecting the hybridization of DNA complementary strands. In our experiments, different DNA oligonucleotides were used as model gene substances. The gene probe is first immobilized on a graphite-epoxy composite working electrode based genosensor. Detection principle is based on changes of impedance spectra of a redox marker, the ferro/ferricyanide couple, after hybridization with target DNA. Resistance offered to the electrochemical reaction serves as the working signal, allowing for an unlabelled gene assay. [Figure not available: see fulltext.]
ACCESSION #
21625720

 

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