TITLE

Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK

AUTHOR(S)
Exley, C.; Esiri, M. M.
PUB. DATE
July 2006
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Jul2006, Vol. 77 Issue 7, p877
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In July 1988, 20 tonnes of aluminium sulphate was discharged by the South West Water Authority into the drinking water supplied to a large region of North Cornwall. Up to 20 000 people were exposed to concentrations of aluminium which were 500–3000 times the acceptable limit under European Union legislation (0.200 mg/l). Although this incident is currently the topic of a government inquiry, nothing is known about its longer-term repercussions on human health. The first neuropathological examination of a person who was exposed and died of an unspecified neurological condition was carried out. A rare form of sporadic early-onset β amyloid angiopathy in cerebral cortical and leptomeningeal vessels, and in leptomeningeal vessels over the cerebellum was identified. In addition, high concentrations of aluminium were found coincident with the severely affected regions of the cortex. Although the presence of aluminium is highly unlikely to be adventitious, determining its role in the observed neuropathology is impossible. A clearer understanding of aluminium's role in this rare form of Alzheimer's related disease should be provided by future research on other people from the exposed population as well as similar neuropathologies in people within or outside this group.
ACCESSION #
21579401

 

Related Articles

  • Still waters. Dixon, Bernard // BMJ: British Medical Journal (International Edition);8/5/95, Vol. 311 Issue 7001, p395 

    Focuses on the effects of the accidental dumping of 20 tons of aluminum sulphate into a reservoir at the local purification plant in Camelford, England. Features of the report published at the `Journal of Psychosomatic Research'; Immediate health effects of the dumping; Features of the public...

  • Aluminium sulphate in water in north Cornwall and outcome of pregnancy. Golding, Jean; Rowland, A.; Greenwood, Rosemary; Lunt, Peter // BMJ: British Medical Journal (International Edition);5/18/91, Vol. 302 Issue 6786, p1175 

    Examines the effect of Aluminum Sulphate water contamination on pregnancy outcomes in Cornwall, England. Dose-related implication of aluminum sulphate for pregnancy miscarriages; Assessments on singleton pregnancies; Absence of evidence to support aluminum sulphate related miscarriages.

  • Chemical amendment of pig slurry: control of runoff related risks due to episodic rainfall events up to 48 h after application. O' Flynn, Cornelius; Healy, Mark; Wilson, Paul; Hoekstra, Nyncke; Troy, Shane; Fenton, Owen // Environmental Science & Pollution Research;Sep2013, Vol. 20 Issue 9, p6019 

    Losses of phosphorus (P) from soil and slurry during episodic rainfall events can contribute to eutrophication of surface water. However, chemical amendments have the potential to decrease P and suspended solids (SS) losses from land application of slurry. Current legislation attempts to avoid...

  • Retrospective study of mortality after a water pollution incident at Lowermoor in north Cornwall. Owen, P J; Miles, D P B; Draper, G J; Vincent, T J // BMJ: British Medical Journal (International Edition);5/18/2002, Vol. 324 Issue 7347, p1189 

    Presents research that analyzes records of death in the population whose records were flagged between July 1988 and December 1997 in Great Britain to compare mortality in an area with water pollution to that in an adjacent area free of pollution. Findings of no statistically significant...

  • An investigation into a treatment strategy for the Berg River water at the Voëlvlei water treatment plant. Swarts, R. J.; Schoeman, J. J. // Water Science & Technology: Water Supply;2012, Vol. 12 Issue 1, p56 

    The main aim of this study was to determine a treatment strategy for the Berg River water at the Voëlvlei water treatment plant (WTP). Jar tests were conducted using ferric and aluminium sulphate as coagulants to determine the optimum treatment parameters of the Berg River water and the...

  • WATER MANAGEMENT OF TWO SHALLOW URBAN EUTROPHIC LAKES. Romo, Susana; Bécares, Eloy // Water Science & Technology;1994, Vol. 30 Issue 10, p299 

    The efficiency and effects of aluminium sulphate on water quality of two shallow urban eutrophic lakes of Madrid (Spain) is reported. Almost all the controlled variables improved with the treatment, especially nutrients, pH and transparency. The application of the method during spring and summer...

  • AUTISM: ASKING THE RIGHT QUESTIONS TO FIND THE RIGHT ANSWERS. Bland, Jeffrey // Alternative Therapies in Health & Medicine;Nov/Dec2008, Vol. 14 Issue 6, p20 

    The article presents the author's views on the concept that autism is caused by the connection of genetic susceptibility factors and the environmental modulators. He thinks that the concept conforms with the principles that guided a therapeutic program for children with brain injuries at the...

  • 30 years' follow-up of randomised studies of adjuvant CMF in operable breast cancer: cohort study. Bonadonna, Gianni; Moliterni, Angela; Zambetti, Milvia; Grazia Daidone, Maria; Pilotti, Silvania; Gianni, Luca; Valagussa, Pinuccia // BMJ: British Medical Journal (International Edition);1/29/2005, Vol. 330 Issue 7485, p217 

    Objective To assess the long term effectiveness of adjuvant treatment with cyclophosphamide, methotrexate, and fluorouracil (CMF) in patients with operable breast cancer at risk of relapse, on the basis of three successive randomised trials and one observational study conducted from June 1973 to...

  • Questions and answers. Abbasi, Kamran // BMJ: British Medical Journal (International Edition);2/5/2005, Vol. 330 Issue 7486, p264 

    Presents an editorial in a question and answer format addressing diverse topics. Question about passive smoking and lung cancer; Question on what has driven whole body CT scanner clinics out of business; Heath issue of dumping aluminum sulphate into a water supply; Value of ski helmets; More.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics