Preoperative Enteral Immunonutrition Improves Postoperative Outcome in Patients with Gastrointestinal Cancer

Jianmin Xu; Yunshi Zhong; Dayong Jing; Zhaohan Wu
July 2006
World Journal of Surgery;Jul2006, Vol. 30 Issue 7, p1284
Academic Journal
Objectives: The purpose of this study was to evaluate the effect of preoperative immunonutrition pharmaceutics (IMPACT) diet versus standard enteral nutrition (EN) on the nutritional status and immunity of patients with colorectal or gastrointestinal (GI) cancer and to evaluate whether it influences the incidence of postoperative complication. Methods: Sixty patients with GI cancer were randomly divided into 2 groups, immunonutrition (IM) and control diet (CT), each of which was fed with IMPACT and conventional diet, respectively, for 7 days before surgical procedures. Variables of nutritional status and immunity, postoperative complications, infections, and the days of postoperative hospitalization were measured. Results: There were no significant differences in the immunological and nutritional variables between the 2 groups preoperatively. The incidence of postoperative complications was significantly lower and the days of postoperative hospitalization were significantly decreased in the IM group. Serum concentrations of both prealbumin (PALB) and transferrin (TRF) were lower in the IM than in the CT group on postoperative day 3 (P < 0.01). TRF continued to be significantly lower in the CT group than in the IM group between day 4 and day 7. However, PALB was significantly lower than before operation in the IM group on postoperative day 3 and TRF was significantly higher in the IM than the CT group on postoperative day 3 (P < 0.05). Both PALB and TRF were significantly higher in the IM than the CT group on postoperative day 7 (P < 0.05). Postoperative immunoglobulin G (IgG) level in the IM group was higher than that in the CT group (13.35 ± 2.06 g/l vs. 9.59 ± 2.23 g/l, P < 0.05). CD4/CD8 ratio was significantly higher in the IM group (2.10 ± 0.51 vs. 1.62 ± 0.52, P < 0.05). Conclusions: Preoperative enteral IM in patients with GI cancer improves nutritional status and immunity and decreases the incidence of postoperative complications and infections.


Related Articles

  • The Role of the Enteral Route and the Composition of Feeds in the Nutritional Support of Malnourished Surgical Patients. Nespoli, Luca; Coppola, Sara; Gianotti, Luca // Nutrients;Sep2012, Vol. 4 Issue 9, p1230 

    In surgical patients, malnutrition is an important risk factor for post-operative complications. In undernourished patients undergoing major gastrointestinal procedures, preoperative enteral nutrition (EN) should be preferred whenever feasible. It may be given either orally or by feeding tubes,...

  • UK surgery already applies aviation safety practice. Lewis, Adam; Smith, Frank; Tait, Peter; Wilkins, Denis // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;3/5/2011, Vol. 342 Issue 7796, p514 

    A letter to the editor is presented in response to an article featuring a debate on translating ideas from aviation to patient safety in the January 14, 2011 issue.

  • Laparoscopic Nephrectomy Outcomes of Elderly Patients in the 21stCentury. Frank C. Lai; Eric L. Kau; Christopher S. Ng; Gerhard J. Fuchs // Journal of Endourology;Nov2007, Vol. 21 Issue 11, p1309 

    Background and Purpose As life expectancy continues to increase, we will be faced with the need to counsel older patients on the risks and benefits of undergoing surgery. It is clear that laparoscopic renal surgery has significant benefits over open renal surgery. However, contemporary data on...

  • New safety standards published for invasive procedures.  // Journal of Perioperative Practice;Oct2015, Vol. 25 Issue 10, p182 

    No abstract available.

  • Are You Ready for Obstructive Sleep Apnea Screening? Atkins, Craig S.; Welliver, Mark; Dalpe Welliver, Dawn // AANA Journal;Feb2013, Vol. 81 Issue 1, p13 

    A letter to the editor is presented in response to the article "Is that Snoring Something to Worry About? Anesthetic Implications for Obstructive Sleep Apnea," by Henrichs and Walsh in the October 2012 issue.

  • A simple trick to facilitate the Schwartzman's maneuver in reduction mammaplasty. Khoo, Lee; Mazzarone, Francesco; Radwanski, Henrique; Pitanguy, Ivo // European Journal of Plastic Surgery;Dec2015, Vol. 38 Issue 6, p515 

    The article discusses the use of infiltrative lipografting cannula to help facilitate the breast reduction operative surgery technique called as Schwartzman's maneuver to avoid complications of deepithelialization in the breast region and mentions instructions for the surgical procedure.

  • The Effects of Music Listening on Changes in Selected Physiological Parameters in Adult Pre-Surgical Patients. Miluk-Kolasa, Barbara; Matejek, Miroslaw; Stupnicki, Romuald // Journal of Music Therapy;Fall1996, Vol. 33 Issue 3, p208 

    The study was aimed at evaluating the effects of music on selected physiological responses of 100 in-patients (72 men and 28 women), aged 20 to 60 years, awaiting non-orthopedic surgery. Patients were randomly assigned to two groups (50 patients per group); control (C) and music listening (M)....

  • The preop eveluation: How much is enough? Abraham, Stephen A.; Fleisher, Lee A.; Lavender, Robert C.; Tape, Thomas G. // Patient Care;2/15/1993, Vol. 27 Issue 3, p149 

    Deals with the disadvantages of too much preoperative testing which can foster a false sense of security and expose patients to needless risk. List of preoperative testing procedures; Factors to consider in assessing the ability to tolerate preoperative stress.

  • The comparison between two different combinations of alar cartilage-modifying techniques: is lateral crural steal the choice? Ghazipour, Ali; Ghadakzadeh, Saber; Karimian, Negar // European Archives of Oto-Rhino-Laryngology;Mar2009, Vol. 266 Issue 3, p391 

    To assess the effect of two different combinations of alar cartilage-modifying techniques on the degree of nasal tip projection and rotation, a prospective trial was performed using preoperative and postoperative photos. The patients were seen in private practice. Sixty patients who had...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics