TITLE

Field Applicability of a Rapid-Format Anti -- Ov-16 Antibody Test for the Assessment of Onchocerciasis Control Measures in Regions of Endemicity

AUTHOR(S)
Lipner, Ettie M.; Dembele, Noumouza; Souleymane, Sanou; Alley, William Soumbey; Prevots, D. Rebecca; Toe, Laurent; Boatin, Boayke; Weil, Gary J.; Nutman, Thomas B.
PUB. DATE
July 2006
SOURCE
Journal of Infectious Diseases;7/15/2006, Vol. 194 Issue 2, p216
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. A previously developed, specific, rapid-format immunochromatographic card test that detects immunoglobulin G4 to the recombinant Onchocerca volvulus antigen Ov-16 was modified to detect antibodies in whole blood. Methods. Ov-16 card test results were assessed in 1511 subjects ⩾2 years of age in 7 West African villages with varying histories of onchocerciasis control measures. Results. In villages in which control measures had been implemented, anti-Ov-16 antibody prevalence rates ranged from 5.2% to 65.1%. Antibody prevalence rates were close to zero among subjects born after effective control measures had been implemented. In 2 villages without a history of control measures where onchocerciasis was endemic, microfilariae (MF) prevalence rates were 82.8% and 65.1%, and antibody prevalence rates were 73.1% and 62.1%. In these 2 villages, the sensitivity of the Ov-16 card test was 81.1% and 76.5%, the specificity was 100%, and the positive predictive value was 91.8% and 80.5%. MF and antibody prevalence rates were correlated (Spearman's r = 0.815; P<.038). Conclusions. The Ov-16 card test is field applicable, exhibits high sensitivity and specificity for O. volvulus infection, and has great potential as a tool for surveillance and for evaluating the success of onchocerciasis control measures.
ACCESSION #
21544264

 

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