TITLE

HLA-A2 -- Restricted Human CD8+ Cytotoxic T Lymphocyte Responses to a Novel Epitope in Vaccinia Virus That Is Conserved among Orthopox Viruses

AUTHOR(S)
Yuzhi Dong; Denny, Thomas N.
PUB. DATE
July 2006
SOURCE
Journal of Infectious Diseases;7/15/2006, Vol. 194 Issue 2, p168
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Classical major histocompatibility complex class I-restricted CD8+ cytotoxic T lymphocytes (CTLs) play an important role in protective immunity against infection with smallpox virus. The identification of target antigens is crucial for defining the role played by CD8+ CTL responses in host resistance to smallpox and for the design of vaccines that produce effective cell-based responses. We report the identification of a novel human leukocyte antigen-A*0201-restricted epitope (J8R11-19) within A55R of vaccinia virus (VV) that is conserved in J8R of smallpox virus variola major. The J8R11-19-specific CTL line and CTL clone exerted physiologically relevant functions as they recognized VV-infected lymphoblastoid JY cells or autologous B lymphoblastoid cell lines, and the cytolytic activity was accompanied by the production of interferon-γ, tumor necrosis factor-α, and interleukin-2. The CTL response was detected in individuals who had been vaccinated >30 years ago or had recently received a booster of current smallpox vaccine (Dryvax) but not in VV-naive donors.
ACCESSION #
21544258

 

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